Morphea is an inflammatory skin condition leading to fibrosis of the and subcutaneous tissue which produces cosmetic functional impairment (FI). Few studies have systematically examined demographic clinical features morphea associated with FI, making it difficult stratify patients for screening FI based on risk. To address this gap, we performed a multicenter cross-sectional analysis adults chi...

Morphea (localized scleroderma) is an autoimmune disease characterized by sclerosis of the skin and, in some cases, subcutaneous tissue. It occurs in children and adults. It is distinct from systemic sclerosis, but may nevertheless be associated with significant functional and cosmetic impairment. Morphea has several distinct subtypes, including circumscribed, linear, and generalized, all of wh...

Morphea is a localized form of scleroderma in which there is predominant skin involvement, with occasional involvement of subjacent muscles and usually spares the internal organs. Thyroid dysfunction has been reported in systemic sclerosis but it has been rarely reported in morphea. There are few case reports of plaque-type morphea associated with autoimmune thyroiditis but generalized morphea ...

IFN: interferon ISR: injection site reaction MS: multiple sclerosis INTRODUCTION Morphea, also known as localized scleroderma, is an uncommon fibrosing condition of the skin and underlying tissue. Although the etiology is unknown, morphea is considered an autoimmune condition in which genetic and environmental factors contribute to disease onset. Although most cases are spontaneous, several inc...

1. Torrelo A, Suárez J, Colmenero I, Azorín D, Perera A, Zambrano A. Deep morphea after vaccination in two young children. Pediatr Dermatol. 2006;23:484--7. 2. Benmously Mlika R, Kenani N, Badri T, Hammami H, Hichri J, Haouet S, et al. Morphea profunda in a young infant after hepatitis B vaccination. J Am Acad Dermatol. 2010;63:1111--2. 3. Bukhari I, Al Breiki S. Post vaccination localized morp...

Morphea, also known as localized scleroderma, encompasses a group of idiopathic sclerotic skin diseases. The spectrum ranges from relatively mild phenotypes, which generally cause few problems besides local discomfort and visible disfigurement, to subtypes with severe complications such as joint contractures and limb length discrepancies. Eosinophilic fasciitis (EF, Shulman syndrome) is often r...

Results Data were available on 44 children. 81.8% were female and 88.6% were Caucasian, of which 13.6% were Latino. Mean age at onset was 8.2 years (± 4.0), yet first evaluation by a pediatric rheumatologist was 9.9 years (± 4.2). Reported subtypes were: 34 linear scleroderma (LiScl: 25 trunk/limbs, 9 face/neck), 7 with circumscribed morphea (CM: 5 deep, 2 superficial), 6 with generalized morph...