The canonical NF-κB pathway is important in inflammatory skin diseases, including contact dermatitis, atopic dermatitis and psoriasis . LUBAC, composed of the HOIP, HOIL-1L SHARPIN, activates through linear ubiquitination NEMO. In this study, to investigate role we used mice lacking RING1 domain, active site (HOIL-1LΔRING1 mice). Since suppresses LUBAC activity, NF-kB promoted transgenic mice. ...

Background: Atopic dermatitis is a chronic, recurrent inflammation of the skin, accompanied by severe pruritus. Immune system dysregulation and skin barrier defects are associated with the abnormalities in atopic dermatitis. Myriad pieces of evidence have pointed to the major roles of LL-37 and interleukin-31 (IL31)in atopic dermatitis. The studies on atopic dermatitis are still limited i...

Indoor, outdoor pollutants and climatic conditions in the growing environment can develop childhood asthma atopic dermatitis. Therefore, it is important to identify environmental burden of community on risk To clarify relationship between regional prevalence rate dermatitis among first grade elementary school students preschool indoor such as smoking rate, photochemical oxidants concentration, ...

Background: Topical corticosteroids are currently used for treatment of diaper dermatitis. Previous studies have shown the efficacy of sucralfate in the treatment of diaper dermatitis and contact dermatitis in peri-stomy areas. Objectives: To evaluate the efficacy of topical sucralfate in comparison with hydrocortisone cream in the treatment of diaper dermatitis. Patients and Methods: In a doub...

BACKGROUND Atopic dermatitis is a chronic, relapsing disorder associated with significant morbidity. Growth retardation is known to occur in children affected with atopic dermatitis. However, there is not enough Indian data for this disorder. AIMS We conducted a longitudinal study to look for the effect of atopic dermatitis on growth attainment of Indian preschool children. METHODS The grow...

Lupi et al. present, on p. 80–81, an interesting case report of dyshidrosiform palmo-plantar pemphigoid. They describe a 20-year-old man who had had itchy vesicles on his palms and soles for 1 year. Histologically, a subepi-dermal vesicle was seen, and direct immunofluorescence showed continuous linear deposition of IgG and C 3 at the dermal-epidermal junction. An enzyme-linked immuno-sorbent a...

Background: Atopic dermatitis is the most common chronic inflammatory dermatitis, due to immunological disorders. Patients with atopic dermatitis are prone to infectious diseases including bacterial infections. On the other hand, atopy may be protective against helminthes parasites. The objective of this study was to compare the frequency and clinical presentations of cutaneous leishmaniasis in...

Vorderman (1901) was the first to record blisters caused by beetles in medical literature. Blister beetle dermatitis is a cutaneous condition caused by the toxins released by blister beetles. The vesicant chemical in the body fluids of these insects causes an acute irritant contact dermatitis characterized by erythematovesicular lesions associated with burning sensation on exposed parts of the ...

We investigated the effect of feeding a skin barrier function-augmenting diet early in dogs' lives on the appearance of clinical signs associated with canine atopic dermatitis. Pregnant bitches (starting 5 weeks after mating) and their subsequent litters (up to 1 year of age) were fed either supplemented or unsupplemented diets. Nutrients supplemented were nicotinamide, pantothenate, histidine,...