Previously, it was found that 5-(3-chlorophenyl)-4-hexyl-2,4-dihydro-3H-1,2,4-triazole-3-thione (TP-315) effectively protects mice from maximal electroshock-induced seizures. The aim of this study was to determine possible interactions between TP-315 and different molecular targets, i.e. GABAA receptors, voltage-gated sodium channels, and human neuronal α7 and α4β2 nicotinic acetylcholine recep...

MthK is a prokaryotic Ca(2+)-gated K(+) channel that, like other ligand-gated channels, converts the chemical energy of ligand binding to the mechanical force of channel opening. The channel's eight ligand-binding domains, the RCK domains, form an octameric gating ring in which Ca(2+) binding induces conformational changes that open the channel. Here we present the crystal structures of the Mth...

introduction: the aim of this study was to evaluate the effect of successful kidney transplantation (kt) on myocardial perfusion and left ventricular function by both qualitative (visual) interpretation and semiquantitative parameters, using myocardial perfusion scintigraphy with gated-single photon emission computed tomography (gated-spect) in patients suffering from end-stage renal disease. ...

objective: although coronary artery disease (cad) is the leading cause of death in type 2 diabetic patients, it is frequently asymptomatic. myocardial perfusion imaging (mpi) is reported to show ischemia in a significant number of asymptomatic diabetic patients. we studied the prevalence and severity of myocardial perfusion defects in asymptomatic diabetic patients and its clinical impact. meth...

Glutamate transporters (also called excitatory amino acid transporters, EAAT) are important in extracellular homeostasis of glutamate, a major excitatory neurotransmitter. EAAT4, a neuronally expressed EAAT in cerebellum, has a large portion (approximately 95% of the total L-aspartate-induced currents in human EAAT4) of substrate-gated Cl(-) currents, a distinct feature of this EAAT. We cloned ...

Many models such as Long Short Term Memory (LSTMs), Gated Recurrent Units (GRUs) and transformers have been developed to classify time series data with the assumption that events in a sequence are ordered. On other hand, fewer for set based inputs, where order does not matter. There several use cases is given partially-ordered sequences because of granularity or uncertainty stamps. We introduce...

Animal venoms contain a fascinating array of divergent peptide toxins that have cross-activities on different types of voltage-gated ion channels. However, the underlying mechanism remains poorly understood. Jingzhaotoxin-III (JZTX-III), a 36-residue peptide from the tarantula Chilobrachys jingzhao, is specific for Nav1.5 and Kv2.1 channels over the majority of other ion channel subtypes. JZTX-...

Myelin protein zero mutations were found to produce Charcot–Marie–Tooth disease phenotypes with various degrees of myelin impairment and axonal loss, ranging from the mild ‘demyelinating’ adult form to severe and early onset forms. Protein zero deficient homozygous mice (P = 0 ) show a severe and progressive dysmyelinating neuropathy from birth with compromised myelin compaction, hypomyelinatio...

Partially observable environments present an important open challenge in the domain of sequential control learning with delayed rewards. Despite numerous attempts during the two last decades, the majority of reinforcement learning algorithms and associated approximate models, applied to this context, still assume Markovian state transitions. In this paper, we explore the use of a recently propo...

Amplification of mRNA from a human antral cell culture preparation demonstrated the presence of two receptors of the bombesin and gastrin-releasing peptide family, GRPR-1 and BRS-3. Single cell microfluorometry demonstrated that most cells that exhibited bombesin-evoked changes in intracellular Ca2+ concentration were gastrin immunoreactive, indicating that antral G cells express the GRPR subty...