BACKGROUND Central to the design of a randomised controlled trial is the calculation of the number of participants needed. This is typically achieved by specifying a target difference and calculating the corresponding sample size, which provides reassurance that the trial will have the required statistical power (at the planned statistical significance level) to identify whether a difference of...

This paper proposes a new replica placement algorithm that expands the exhaustive search limit with reasonable calculation time. It combines a new type of parallel data-flow processor with an architecture tuned for fast calculation. The replica placement problem is to find a replica-server set satisfying service constraints in a content delivery network (CDN). It is derived from the set cover p...

We present a calculation of the Vector Form Factor at the next-to-leading order in the 1/NC expansion, within the framework of Resonance Chiral Theory. The calculation is performed in the chiral limit, and with two dynamical quark flavours. The ultraviolet behaviour of quantum loops involving virtual resonance propagators is analyzed, together with the kind of counterterms needed in the renorma...

In this study the centre manifold is applied for reduction and limit cycle calculation of a highly nonlinear structural aeroelastic wing. The limit cycle is arisen from structural nonlinearity due to the large deflection of the wing. Results obtained by different orders of centre manifolds are compared with those obtained by time marching method (fourth-order Runge-Kutta method). These comparis...

Kanji Hioka Graduate School of Science and Engineering, Yamaguchi University 1677-1 Yoshida, Yamaguchi 753-8512, Japan [email protected] Yoshimasa Miwa Graduate School of Science and Engineering, Yamaguchi University 1677-1 Yoshida, Yamaguchi 753-8512, Japan [email protected] Chen Li Human Genome Center, University of Tokyo 4-6-1 Shirokanedai, Minatoku, Tokyo 108-8639, Ja...

A sample size calculation for logistic regression involves complicated formulae. This paper suggests use of sample size formulae for comparing means or for comparing proportions in order to calculate the required sample size for a simple logistic regression model. One can then adjust the required sample size for a multiple logistic regression model by a variance inflation factor. This method re...

Exact power and sample size calculation for bioequivalence studies with high order crossover designs using statistical software nQuery are presented. Such calculation can be very easily performed, and thus provides a convenient tool for practical usage.

In clinical research, parameters required for sample size calculation are usually unknown. A typical approach is to use estimates from some pilot studies as the true parameters in the calculation. This approach, however, does not take into consideration sampling error. Thus, the resulting sample size could be misleading if the sampling error is substantial. As an alternative, we suggest a Bayes...