Physarum polycephalum hemagglutinin I (HA1) is a 104-residue protein that is secreted to extracellular space. The crystal structure of HA1 has a β-sandwich fold found among lectin structures, such as legume lectins and galectins. Interestingly, the β-sandwich of HA1 lacks a jelly roll motif and is essentially composed of two simple up-and-down β-sheets. This up-and-down β-sheet motif is well co...

Prediction of functional peptide motifs from sequences is an important problem in bioinformatics. Experimental discovery of functional sequences is laborious. Searches for specific motifs within the increasing number of proteins available in public databases often involve extensive computer calculations. Short peptide motifs are especially hard to identify via currently available methods. Prese...

Abstract Two unnatural regioisomeric glycosylated Gilvocarcin analogues were proposed as model compounds to study the origin behind biosynthetic development of Gilvocarcins, a class bioactive C ‐aryl glycoside natural products. More specifically, origins O ‐ ‐glycoside migration in evolution biosynthesis for these classes Angucycline antibiotic For stability reasons 5a‐carbasugar motif was used...

Draper, a receptor responsible for the phagocytosis of apoptotic cells in Drosophila, possesses atypical epidermal growth factor (EGF)-like sequences in the extracellular region and the two phosphorylatable motifs NPxY and YxxL in the intracellular portion. We previously suggested that Pretaporter, a ligand for Draper, binds to the EGF-like repeat and augments the tyrosine phosphorylation of Dr...

The vesicular glutamate transporters (VGLUTs) package glutamate into synaptic vesicles, and the two principal isoforms VGLUT1 and VGLUT2 have been suggested to influence the properties of release. To understand how a VGLUT isoform might influence transmitter release, we have studied their trafficking and previously identified a dileucine-like endocytic motif in the C terminus of VGLUT1. Disrupt...

The ADAM (a disintegrin-like and metalloproteinase) proteins are a family of transmembrane cell-surface proteins with important functions in adhesion and proteolytic processing in all animals. Human ADAM-15 is the only member of the ADAM family with the integrin binding motif Arg-Gly-Asp (RGD) in its disintegrin-like domain. This motif is also found in most snake venom disintegrins and other di...

Insulin regulates the expression of more than 150 genes, indicating that this is a major action of this hormone. At least eight distinct consensus insulin response sequence (IRSs) have been defined through which insulin can regulate gene transcription. These include the serum response element, the activator protein 1 ('AP-1') motif, the Ets motif, the E-box motif and the thyroid transcription f...

Abstract In Judg 14–15, the source of Samson’s strength is not his uncut hair, but רוח־יהוה . A Leitmotif biblical warrior tradition, a corporealized metaphor fiery anger that envelops Samson and grants him great power. This motif was adapted from early poetry, in which Yhwh’s wrath erupted as breath ( רוח ) against cosmic foes. study explores how historical context 14–15 informs use this motif...