OBJECTIVE To investigate the response of the somatotrope axis (insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3)) to intense exercise in relation to tiredness. METHODS The study involved 11 rugby players who completed a questionnaire intended to evaluate fitness or, conversely, overtraining and who agreed to plasma samples being taken before and afte...

Department of Cell Biology and Anatomy, University of Miami School of Medicine (G.R.G.), Miami, Florida 33136; Department of Molecular Genetics, University of Illinois College of Medicine (L.F.L.), Chicago, Illinois 60607; Laboratoire d’Oncologie Virale et Moléculaire, UFR de Biochimie, Université Paris 7 (B.P.), 75005 Paris, France; and INSERM U-515, Hôpital Saint Antoine (B.P.), Paris 75012, ...

We investigated the acute (4-5 h) and short-term (5 days) effects of GH treatment on hepatic messenger RNA (mRNA) levels of the genes for the insulin-like growth factors (IGFs), insulin-like growth factor binding protein-1, -2, and -3 (IGFBPs), and the acid labile subunit (ALS), as well as serum levels of these proteins in humans. At the mRNA level, we observed an increase in IGF-1 transcriptio...

The effects of acute stressor exposure on proximal (growth hormone [GH]) and distal (insulin-like growth factor-I [IFG-I] and insulin-like growth factor-binding proteins [IFGBPs]) components of the somatotropic axis are poorly understood in finfish. Rainbow trout (Oncorhynchus mykiss) were exposed to a 5-min handling disturbance to mimic an acute stressor episode, and levels of plasma GH, IGF-I...

The authors provide a nice summary of our recent report on how growth hormone (GH) regulates neonatal inflammatory pain.We still need to understand how GH is downregulated during peripheral injury and how this reduction causes a paradoxical increase in sensory neuron IGFr1. To clarify, IGF-1 was not statistically increased in the skin as suggested. Furthermore, although not confirmed in vivo, i...

Insulin-like growth factor I (IGF-I) binding protein-5 (IGFBP-5) is produced by mesangial cells (MCs) and likely functions to modulate glomerular IGF-I activity. Although IGFBP-5 may be inhibitory for IGF-stimulated MC activity, preliminary studies suggested that IGFBP-5 acts directly on MCs. To investigate this further, we evaluated the effects of IGFBP-5 on rat MC migration. We found that the...