Background: Cancer stem-like cells (CSCs) play a crucial role in the initiation, progression, and recurrence of cancer. Evidence indicates that the high linear energy transfer (LET) carbon ion beam is more effective against CSCs than the conventional X-ray beam. Carbon ion radiotherapy is considered as a promising cancer strategy, however, information about whether, or not, new CSCs are induced...

seizure activity has been proposed to result in the generation of reactive oxygen species (ros), which then contribute to seizure-induced neuronal damage and eventually cell death. although the mechanisms of seizure-induced ros generation are unclear, mitochondria and cellular calcium overload have been proposed to have a crucial role. we aim to determine the sources of seizure-induced ros and ...

Title Copy number and sequence variation of leucine-rich repeat modules suggests distinct functional constraints operating on variable lymphocyte receptors expressed by agnathan T cell-like and B cell-like lymphocytes Author(s) Sutoh, Yoichi; Kasahara, Masanori Citation Immunogenetics, 66(6): 403-409 Issue Date 2014-06 Doc URL http://hdl.handle.net/2115/59437 Right The original publication is a...

background: embryonic stem (es) cells are pluripotent cells conventionally isolated from early embryos. studies have shown that es cells serve as a practical model for biomedical studies. objective: the aim of the present study was to optimize culture conditions for establishment of es-like colonies from nmri mouse blastocysts as well as 2-cell stage embryos. materials and methods: both expande...

Lymphoepithelial - like carcinoma, is rarely recognized in the urinary bladder and less commonly occurs with papillary transitional cell carcinoma i.e. mixed pattern. Also, less uncommon is the occurrence of carcinoma in situ changes in the adjacent urothelium of these tumors. Here, a case of lymphoepithelial – like carcinoma and papillary transitional cell carcinoma associated with carci...

background: we had previously identified the genes involved in squamous cell carcinoma of the head and neck using differential display and dna microarray techniques. we also reported the first analytical study on a novel human gene called loc92912, which was identified by differential display as a gene up-regulated in such carcinomas. loc92912, which is a putative member of the e2 ubiquitin con...