BACKGROUND Platelet reactivity assessment is an important tool in both the causal determination of bleeding diathesis as well as in the evaluation of the efficacy of anti-platelet therapy in patients at risk of thrombosis. Sodium citrate is the most widely used anticoagulant for hemostasis investigations. However, some doubt exists over the suitability of sodium citrate in platelet function tes...

Cryogen spray cooling (CSC) is a technique employed to reduce the risk of epidermal damage during dermatologic laser surgery. However, while CSC protects the epidermis from non-specific thermal damage, it might reduce the effective fluence reaching the target chromophore due to scattering of light by the spray droplets and subsequent water condensation/freezing on the skin surface. The objectiv...

In Reply: Drs. Slater and Lerner have reemphasized a critical point in our published case scenario1: Standard coagulation tests are inadequate in assessing adequacy of platelet function for epidural catheterization. Therefore, we recommended in our algorithm presented in figure 4 of our original report1 to use whole blood multiple electrode impedance aggregometry (Multiplate®; Roche Diagnostics...

We propose a spectral prediction model for predicting the reflectance and transmittance of recto-verso halftone prints. A recto-verso halftone print is modeled as a diffusing substrate surrounded by two inked interfaces in contact with air (or with another medium). The interaction of light with the print comprises three components: (a) the attenuation of the incident light penetrating the print...

The translucency of comparable shades of five dental porcelains was determined. Both direct transmittance and total transmittance were measured at wavelengths of 400-700 nm. For 1 mm of porcelain, the values for direct transmittance were low and averaged 0.13 percent, whereas the values for total transmittance averaged 26.8 percent. Transmittance increased with increasing incident wavelength. T...

OBJECTIVES The aim of this study was to evaluate the impact of the phosphodiesterase (PDE) inhibitor pentoxifylline on platelet function profiles in patients receiving dual antiplatelet therapy (DAPT). BACKGROUND Previous studies have shown that, in patients receiving DAPT, the adjunctive use of a PDE inhibitor enhances platelet inhibition, particularly in those presenting with diabetes melli...

Abstract. This paper presents result of a study on radiation damage and recovery for lead tungstate crystals produced at BTCP and SIC. Correlations were observed between initial light output and initial longitudinal transmittance at 360 nm, between the loss of longitudinal transmittance at 440 nm and the loss of light output, and between radiation damages levels at different dose rates. No corr...

Abstract Objectives To rule out a drug-drug interaction (DDI) among cangrelor-treated patients who have been pre-treated with ticagrelor. Background There are no studies specifically designed to DDI when cangrelor is used Methods In this prospective, randomized, double-blind, placebo-controlled, cross-over, pharmacokinetic (PK) and pharmacodynamic (PD) study, coronary artery disease (n = 20) we...

Light is a key resource for plant growth and is of particular importance in forest ecosystems, because of the strong vertical structure leading to successive light interception from canopy to forest floor. Tree species differ in the quantity and heterogeneity of light they transmit. We expect decreases in both the quantity and spatial heterogeneity of light transmittance in mixed stands relativ...

Aggregometry and genotyping are methods of platelet function testing, which can be beneficial for high-risk patients undergoing invasive cardiac procedures. An optimal level of platelet reactivity (PR) should be maintained. There are discrepancies between individuals and their response to clopidogrel, accounting for the incidence of poor responders from 5% to 44%. This phenomenon predisposes th...