Homoleptic LiNacNac forms simple donor–acceptor complexes with N,N′-dicyclohexylcarbodiimide (CyN═C═NCy), triphenylphosphine oxide (Ph3P═O), and benzophenone (Ph2CO). These crystallographically characterized compounds could be regarded as model intermediates en route to reducing the N═C, P═O, C═O bonds of unsaturated substrates. Heteroleptic NacNacMg(TMP) intriguingly functions a TMP nucleophil...

Convergent preparative routes to new urea-pyrazolate dinucleating ligands are described. Metal complexes of these ligands have hydrogen bond donors that are proximal to the metal centers that interact with other coordinated species. This is exemplified by Co(II) dimers with Co(II)-mu-Cl-Co(II) motifs, in which the chloro ligand is involved in four intramolecular hydrogen bonds. These noncovalen...

In the mononuclear title salt, [Ag(C3H8N2S)(C18H15P)3](CH3COO), the Ag(I) ion exhibits a distorted tetra-hedral coordination sphere defined by three P atoms from three tri-phenyl-phosphane ligands and one S atom from a 1,3-di--methyl-thio-urea ligand. In the crystal, the acetate anion is linked with the complex cation via duplex N-H⋯O hydrogen bonds [graph-set motif R (2) 2(8)].

Fluorescence spectroscopy was used to study some aspects of thermal denaturation of lactate dehydrogenase (LDH) from rabbit muscle, in the absence and presence of urea and NaCl. Thermal denaturation of LDH seems to be one step and a slightly reversible process. The solution pH has an important influence on the LDH thermal denaturation. The interaction of LDH enzyme with NADH ligand was also inv...

In the title coordination polymer, [CuI(C(13)H(14)N(4)S)](n), the Cu(I) atom is coordinated by two N atoms from two N,N'-bis-(3-pyridylmeth-yl)thio-urea ligands, as well as by the S atom of a third ligand and an I atom to confer a distorted tetra-hedral coordination at the metal centre. The coordination bonds give rise to a layer structure parallel to (010).

A tetraphenylethene (TPE)-decorated tripodal tris(urea) ligand was synthesized, which shows large emission enhancement when binding to an orthophosphate anion (PO4(3-)), but exhibits only weak or no fluorescence with other anions. The anion-binding and fluorescence properties were studied by X-ray crystal structure, NMR and fluorescence spectroscopy, and by DFT computations and the results demo...

By the use of a rapid dialysis equilibrium technique, the binding of skatole and acetyl-L-tryptophan with bovine albumin has been studied at various concentrations of KCl, dioxane, urea, and glycine, at different pH values, and at different temperatures. Binding was found to be principally at one site with an association constant much higher than at any secondary sites. The primary association ...

The asymmetric unit of the title compound, [Cu(NCS)(C3H8N2S)(C27H26P2)], contains two independent mononuclear complex mol-ecules. In each, the Cu(I) ion exhibits a distorted tetra-hedral geometry by coordination with two P atoms from one 1,3-bis(diphenylphosphino)propane (dppm) ligand, one terminal S atom of one N,N'-di-methyl-thio-urea (dmtu) ligand and one terminal N atom of the thio-cyanato ...

EphA2, a member of the large family of Eph receptor tyrosine kinases, is highly expressed in epithelial tissue and has been implicated in cell-cell and cell-matrix interactions, as well as cell growth and survival. Expression of EphA2 mRNA and protein was markedly upregulated by both hypertonic stress and by elevated urea concentrations in cells derived from the murine inner medullary collectin...

Micronutrients such as siderophore-bound iron and vitamin B(12) cross the outer membrane of gram-negative bacteria through a group of 22-stranded beta-barrel proteins. They share the unusual feature that their N-terminal end inserts from the periplasmic side into the beta-barrel and plugs the lumen. Transport results from energy-driven movement of TonB protein, which either pulls the plug out o...