Lichen sclerosus is a chronic inflammatory disease, usually located in the genital area. The etiology of lichen sclerosus is multifactorial, with participation of genetic, autoimmune, infectious and hormonal factors. Bullous clinical form stems from hydropic degeneration of the basal membrane, constituting a less frequent variant of the disease. In this work, we report the case of a female pati...

Lichen sclerosus et atrophicus (LSA), also called Lichen sclerosus (LS) is a chronic, benign, depigmenting disease of the skin and mucous membranes, most frequently affecting genital mucosa and skin. Involvement of the oral mucosa without concurrent genital or skin lesions has very rarely been reported in the literature. Here we report on two Chinese women with LSA limited to the dorsum of the ...

Vulvar melanoma is the second most common vulvar cancer. Patients with vulvar melanoma usually present with the disease at a late stage and have a poor prognosis. The prognostic predictors reported in the literature are not unequivocal and the role of lichen sclerosus and c-KIT mutations in the aetiology of vulvar melanoma is unclear. Breslow staging currently seems to be the most adequate pred...

BACKGROUND Lichen sclerosus is a chronic inflammatory disease with a predilection of the anogenital region. Because of the potential side effects of repeated local application of potent glucocorticosteroids, equally-effective, safer therapeutic options are required, especially in the treatment of children. CASE PRESENTATIONS We report on the efficacy of twice-daily application of pimecrolimus...

Lichen sclerosus or lichen sclerosus et atrophicus is a chronic inflammatory disease predominantly affecting the genital mucosa and skin. Clinically, it is characterized by white atrophic plaques in the anogenital region. The lesions are generally asymptomatic, but may cause discomfort with itching and pain. Extragenital mucosal involvement is very unusual, and lesions limited to the oral mucos...

A patient reported to the Florida Spine Institute (Clearwater, Fla., USA) with severe lichen sclerosus of the anogenital region and legs. The patient's pain presentation was neuropathic with hypersensitivity, allodynia, swelling, and weakness. The patient had failed multiple pain management modalities including opioid therapy, anticonvulsants, and antidepressants. The patient completed a standa...

1. Torrelo A, Suárez J, Colmenero I, Azorín D, Perera A, Zambrano A. Deep morphea after vaccination in two young children. Pediatr Dermatol. 2006;23:484--7. 2. Benmously Mlika R, Kenani N, Badri T, Hammami H, Hichri J, Haouet S, et al. Morphea profunda in a young infant after hepatitis B vaccination. J Am Acad Dermatol. 2010;63:1111--2. 3. Bukhari I, Al Breiki S. Post vaccination localized morp...

1. Torrelo A, Suárez J, Colmenero I, Azorín D, Perera A, Zambrano A. Deep morphea after vaccination in two young children. Pediatr Dermatol. 2006;23:484--7. 2. Benmously Mlika R, Kenani N, Badri T, Hammami H, Hichri J, Haouet S, et al. Morphea profunda in a young infant after hepatitis B vaccination. J Am Acad Dermatol. 2010;63:1111--2. 3. Bukhari I, Al Breiki S. Post vaccination localized morp...

Lichen planus pemphigoides (LPP) is a rare blistering disease with features of both lichen planus and bullous pemphigoid. LPP typically appears on the extremities and occasionally involves the oral mucosa. Herein, we describe a case of LPP of the vulva of an 80-year-old woman, an uncommon location for this disease process. This clinical scenario can be confused with a number of similarly appear...