نتایج جستجو برای: leydig cell

تعداد نتایج: 1685262  

Journal: :Advances in anatomy, embryology, and cell biology 2009
Michail S Davidoff Ralf Middendorff Dieter Müller Adolf F Holstein

The Leydig cells of the testis represent the main source of androgens. The idea of Leydig cells as endocrine cells has been the leading characteristic of this interesting cell population till now. Our studies of the last 2 decades allowed us to reveal a new important feature of Leydig cells that is their obvious similarity with structures of the central and peripheral nervous system. This inclu...

Journal: :The Journal of Cell Biology 2004
Michail S. Davidoff Ralf Middendorff Grigori Enikolopov Dieter Riethmacher Adolf F. Holstein Dieter Müller

The cells responsible for production of the male sex hormone testosterone, the Leydig cells of the testis, are post-mitotic cells with neuroendocrine characteristics. Their origin during ontogeny and regeneration processes is still a matter of debate. Here, we show that cells of testicular blood vessels, namely vascular smooth muscle cells and pericytes, are the progenitors of Leydig cells. Res...

Journal: :Environmental Health Perspectives 1981
L L Ewing B R Zirkin C Chubb

Advances in two techniques have made the problem of assessing the acute and/or chronic effects of toxic agents on Leydig cell structure and testosterone synthesis and secretion amenable to study. First, in vitro testicular perfusion has been perfected to a point where it closely resembles in situ testosterone secretion. Second, now it is possible to quantify the proportion of Leydig cell cytopl...

Journal: :Asian journal of andrology 2007
Wei-Ran Chai Qian Wang Hui-Bao Gao

AIM To investigate the activation of the nuclear factor of activated T cells (NFAT) and its function in the corticosterone (CORT)-induced apoptosis of rat Leydig cells. METHODS NFAT in rat Leydig cells was detected by Western blotting and immunohistochemical staining. Cyclosporin A (CsA) was used to evaluate potential involvement of NFAT in the CORT-induced apoptosis of Leydig cells. Intracel...

2015
Salwan Maqdasy Laura Bogenmann Marie Batisse-Lignier Béatrice Roche Fréderic Franck Françoise Desbiez Igor Tauveron

49,XXXXY pentasomy or Fraccaro's syndrome is the most severe variant of Klinefelter's syndrome (KS) affecting about 1/85000 male births. The classical presentation is the triad: mental retardation, hypergonadotropic hypogonadism and radio ulnar synostosis. Indeed, the reproductive function of Fraccaro's syndrome is distinguished from KS. Besides, Leydig cell tumors are described in cases of KS,...

Journal: :PLoS ONE 2008
Jun Qin Ming-Jer Tsai Sophia Y. Tsai

Chicken Ovalbumin Upstream Promoter-Transcription Factor II (COUP-TFII; also known as NR2F2), is an orphan nuclear receptor of the steroid/thyroid hormone receptor superfamily. COUP-TFII-null mice die during the early embryonic development due to angiogenesis and cardiovascular defects. To circumvent the early embryonic lethality and investigate the physiological function of COUP-TFII, we knock...

Journal: :Asian journal of andrology 2006
Qian Wang Hui-Bao Gao

AIM To investigate the activation of nuclear factor-kappa B (NF-kappa B) and its function in glucocorticoid-induced Leydig cell apoptosis. METHODS The Leydig cells were isolated from male Sprague-Dawley rats (90 days of age) and were incubated with corticosterone (CORT, glucocorticoid in rat) for 6 h, 12 h and 24 h, respectively. The P65 subunit of NF-kappa B (NF-kappa B/P65) in nuclei and th...

Journal: :The Journal of biological chemistry 1980
A H Payne K L Wong M M Vega

Luteinizing hormone (LH) receptor sites and in vitro testosterone production in response to human chorionic gonadotropin (hCG) stimulation (Leydig cell responsiveness) were studied in two distinct populations of Leydig cells after different modes of in vivo gonadotropin treatments. Dispersed cells from decapsulated rat testes were purified and separated into two distinct populations of Leydig c...

Journal: :Endocrinologia japonica 1988
M Takase K Tsutsui S Kawashima

The aim of this study is to examine the influence of Sertoli cells on LH binding to Leydig cells in culture in immature mice. Leydig cells and Sertoli cells were obtained from the testes of immature C57BL/6Ncrj mice and were cultured in serum-free medium for 7 days. The LH binding to Leydig cells and the FSH binding to Sertoli cells were dependent on incubation time, the number of cells, and th...

2013
Soyi Lim Na-Rae Kim Kwang-Beom Lee

Sertoli-Leydig tumors tend to relapse early and due to their rarity, limited data are available regarding a role of chemotherapy in the management of Sertoli-Leydig cell tumors. We present a case of recurrent ovarian Sertoli-Leydig cell tumor whose salvage treatment was successful with paclitaxel and carboplatin chemotherapy.

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