Leukocyte adhesion deficiency (LAD) is characterized by the inability of leukocytes, in particular neutrophilic granulocytes, to emigrate from the bloodstream towards sites of inflammation. Infectious foci are nonpurulent and may eventually become necrotic because of abnormal wound healing. LAD-1 is characterized by the absence of the beta2 integrins (CD11/CD18) on leukocytes. When expression i...

PURPOSE In experimental autoimmune uveitis (EAU), recent work has demonstrated that retinal damage involves oxidative stress early in uveitis, before macrophage cellular infiltration. The purpose of this study was to determine whether oxidative mitochondrial DNA damage occurs early in EAU, before leukocyte infiltration. METHODS Lewis rats were immunized with S-antigen mixed with complete Freu...

The Authors studied the cell mediated immunity (CMI) and humoral antibody levels raised in response to canine antirabies vaccination and re vaccination. The vaccine used was the FUENZALIDA & PALACIOS which is routinelly utilized in human and canine vaccination in Brazil. The evaluation of CMI was done by inhibition of peripheral leukocyte migration and antibody levels were measured by serum neu...

The referee is correct about the bias introduced by seasonality, and a simple average of GLAS LAI over different months supports this hypothesis: 3.02 for May, 3.14 for June, 2.93 for October and 2.22 for November. However, we did not exclude the leaf flushing/senescence periods because we tried to maximize the usage of GLAS shots. The GLAS/ICESat mission was not operated year round but deploye...

Streptococcus pneumoniae contributes to a range of infections, including meningitis, pneumonia, otitis media, and sepsis. Infections by this bacterium have been associated with the phenomenon molecular mimicry, which, in turn, may contribute induction autoimmunity. In study, we utilized bioinformatics approach investigate potential for S. incite autoimmunity via mimicry. We identified 13 protei...

The bone marrow is an important source of Abs involved in long-term protection from recurrence of infections. Allogenic bone marrow transplantation (BMT) fails to restore this working memory. Attempts to overcome this immunodeficiency by immunization of the donor have not been very successful. More needs to be known about transfer of B cell memory by BMT. We tracked memory B cells from the dono...

introduction: studies have shown that insufficient recovery between sessions causes immune suppression. the aim of this study was to investigate the effect of repeated bouts resistance and endurance exercise on blood leukocytes, lymphocytes, neutrophils, monocytes count and plasma cortisol levels in athlete girls. materials and methods: 9 athlete girls (ages, 20-25 years), participated in the s...

It would be extremely beneficial if one could harness natural, endogenous, health-promoting defense mechanisms to fight disease and restore health. The psychophysiological stress response is the most underappreciated of nature's survival mechanisms. We show that acute stress experienced before primary immunization induces a long-lasting increase in immunity. Compared with controls, mice restrai...