Researchers in the eld of Distributed Arti cial Intelligence DAI have been developing e cient mechanisms to coordinate the activities of multi ple autonomous agents The need for coordina tion arises because agents have to share resources and expertise required to achieve their goals Previous work in the area includes using sophis ticated information exchange protocols investi gating heuristics ...

Con tent: The suc cess ful in tro duc tion of ev i dence-based prac tice into psy chi a try re quires the ac qui si tion of new skills by cli ni cians. It is also im por tant that pol icy state ments that aim to be ev i dence-based, such as clin i cal prac tice guide lines, use rig or ous meth ods to syn the size the pri mary ev i dence and do not over look its lim i ta tions. One re sult of th...

On a global scale, athalassic inland salt lakes are abundant, albeit restricted to semiarid and arid climates. La Salada de Chiprana is unique in Western Europe, because it is a permanent and relatively deep (up to 5.6 m) hypersaline lake (40–90 g total dissolved salt L–1) since 1700 AD. It forms part of a cultural landscape, which imposes a chal‐ lenge for management. The aim of this paper is ...

Preparing an index to a book or assigning indexing terms to documents involves the task of subject analy sis. Subject analysis can be defined as "the intellectual or automated process by which the subjects of a docu ment are analyzed for subsequent expression in the form of subject data'.1 Is automatic indexing a chal lenge, or even a threat to indexers? What do we mean when we talk about "subj...

The phase behavior and physical properties of lipids in biological membranes are exquisitely sensitive to changes in temperature (50). Because membranes (a) act as physical barriers to solute diffusion, (b) mediate the transmembrane movement of specific solutes, (c) regulate the utilization of energy stored in transmembrane ion gradients, Cd) provide an organizing matrix for the assem­ bly of m...

Tumor necrosis factor (TNF) kills some types of tumor cells in vitro and participates in tumor elimination in vivo. TNF has been shown to kill cells by altering their mitochondria structurally and functionally. The oncogene l<( I -2 codes for a protein located in the inner membrane of mitochondria which is able to inhibit the commitment to cell death in various cell types. We have therefore inv...

Whether it is possible to build up host resistance against sarcomas induced by the implantation of cellophane films was studied by pretreating autochthonous and isologous (syngeneic) hosts with heavily irradiated cells of the same tumor. In the ten available autochthonous hosts, whose tumors had been operatively removed, no resist ance could be demonstrated after pretreatment with irradiated ce...

Numerous studies dissecting the basic mechanisms that control sleep regulation have led to considerable improvement in our knowledge of sleep disorders. It is now well accepted that transitions between sleep and wakefulness are regulated by complex neurobiologic mechanisms, which, ultimately, can be delineated as oscillations between two opponent processes, one promoting sleep and the other pro...

Four transplantable mammary tumors, three (66, 410, and 168cl) isolated from a spontaneously occurring strain BALB/ cfCSH mammary tumor and one (D2) arising from a BALB/c hyperplastic alveolar nodule were found to grow better in mammary fatpads than at s.c. sites. Furthermore, tumor growth was better (p < 0.05) in intact mammary glands than in cleared mammary fatpads for the D2, 410, and 66 tum...