Cardiovascular complications are a major source of morbidity and mortality in hypertensive patients. To assess the prevalence of anatomic and functional abnormalities of the heart in such patients, we studied 234 asymptomatic subjects with mild-to-moderate systemic hypertension by echocardiography. After adjusting the echocardiographic values for age and body surface area, we found abnormally i...

Cardiac dimensions and left ventricular function were investigated at rest with non-invasive methods in 14 professional road race cyclists and in 11 age-matched sedentary control subjects. The electrocardiographic findings were in agreement with previous studies in endurance athletes and the vectocardiographic data showed anterior displacement of the electrical forces. Echocardiographic dimensi...

BACKGROUND We assessed a novel simultaneous biventricular mapping and ablation approach for septal ventricular tachycardia (VT) in a chronic ovine infarct model. METHODS AND RESULTS In 8 sheep with inducible VT, mapping and ablation were performed 9+/-3 months after percutaneously induced myocardial infarction, with left ventricular ejection fraction 23+/-8%. Scar was identified by EnSite Dyn...

Objective: To evaluate symptomatic and haemodynamic results of transcoronary ablation of septal hypertrophy for hypertrophic obstructive cardiomyopathy in elderly patients. Setting: Tertiary referral centre for patients with hypertrophic obstructive cardiomyopathy. Design: Retrospective study of two groups of consecutive patients divided at a median age (59 years). Patients: Transcoronary ablat...

OBJECTIVE To evaluate symptomatic and haemodynamic results of transcoronary ablation of septal hypertrophy for hypertrophic obstructive cardiomyopathy in elderly patients. SETTING Tertiary referral centre for patients with hypertrophic obstructive cardiomyopathy. DESIGN Retrospective study of two groups of consecutive patients divided at a median age (59 years). PATIENTS Transcoronary abl...

Echocardiographic patterns in 15 patients with hypertrophic cardiomyopathy were compared with those in 30 healthy persons. Correlations with angiocardiographic data indicated that most of the anatomical abnormalities in hypertrophic cardiomyopathy can be assessed reliably by echocardiography. These include abnormal mitral valve motion, a reduction of the anteroposterior dimension of the left ve...

We previously reported on two male sibs with an unknown syndrome which included microcephaly, seizures, mental retardation, congenital heart disease, and skeletal abnormalities.' The subsequent clinical course and necropsy findings of one of the boys (sib 2) contribute substantial information to the original report. At 15 months of age he had findings of a large atrial septal defect with signif...

A 14-year-old girl presented to an outpatient clinic for evaluation of dizziness and fainting. She had been diagnosed with congenital hypertrophic cardiomyopathy (HCMP) after birth. Her father was 45 years old and had asymptomatic HCMP (septal wall thickness, 3.0 cm). Her younger sister also had septal hypertrophy (septal wall thickness, 3.5 cm). Her mother had no history of gestational diabete...

BackgroundIncreased metabolic rate of hyperglycemia in gestational diabetes causes macrosomia, which can also affect the fetal heart. The thickness of the walls of the heart and its function in women with gestational diabetes mellitus (GDM) can change over time before treatment. We aimed to evaluate fetal cardiac structure in terms of ventricular wall thickness and its function in women w...