Patients with diabetes are at a higher risk of having diabetic foot ulcers (DFUs) or necrotizing fasciitis (NF). The present study aims to examine the clinical characteristics and associated risk factors for lower-extremity amputation (LEA) in patients with DFU complicated by NF.We retrospectively reviewed patients treated at a major diabetic foot center in Taiwan between 2009 and 2014. Of the ...

OBJECTIVE The goal of the study was to determine whether complications of diabetes well-known to be associated with death such as cardiovascular disease and renal failure fully explain the higher rate of death in those who have undergone a lower-extremity amputation (LEA). RESEARCH DESIGN AND METHODS This was a longitudinal cohort study of patients cared for in the Health Improvement Network....

The ability of certain plants, invertebrates, and microorganisms to survive almost complete loss of water has long been recognized, but the molecular mechanisms of this phenomenon remain to be defined. One phylogenetically widespread adaptation is the presence of abundant, highly hydrophilic proteins in desiccation-tolerant organisms. The best characterized of these polypeptides are the late em...

The large external antigen (LEA) is a cell surface glycoprotein that has been proven to be highly expressed in colorectal cancer (CRC) as a tumor-associated antigen. To evaluate and validate the relationship between LEA expression and clinical characteristics of CRC with high efficiency, LEA expression levels were detected in 85 tissue blocks from CRC patients by quantum dot-based immunohistoch...

Studies in anhydrobiotic plants have defined many genes which are upregulated during desiccation, but comparable studies in invertebrates are at an early stage. To develop a better understanding of invertebrate anhydrobiosis, we have begun to characterise dehydration-inducible genes and their proteins in anhydrobiotic nematodes and bdelloid rotifers; this review emphasises recent findings with ...

The present study was undertaken with a rationale that loss of certain "normal tissue" antigens might have prognostic significance, reflecting inactivation of the corresponding genes during neoplastic progression. An attempt was made to identify such antigens by means of generating mon oclonal antibodies using a tolerization/immunization procedure. A mono clonal antibody generated by immunizati...

LEA proteins represent severa1 families of proteins that accumulate to high levels in maturing seeds. The expression of these proteins is under developmental control, but they may also be expressed in dissected embryos exposed to exogenous ABA (Hughes and Galau, 1991). Many Leu genes are also expressed in vegetative tissues exposed to exogenous ABA as well as water, osmotic, and low-temperature...

Conventional manual transmissions suffer from deterioration due to wear and reduced responsiveness. Therefore, a linear electromagnetic actuator (LEA) for gear shifting has been developed. Since the LEA is direct drive, it prevents high In addition, this holding force by detent at three points. paper, sensorless position estimation performed simplify system. one coil not energized during drivin...

OBJECTIVE Compare the performance of Lea Symbols and Sheridan Gardiner charts against the standard test chart used to determine reduced VA during vision screening among pre-schoolers. MATERIAL AND METHOD Seven hundred seventy five pre-school participated where 389 subjects were boys and 386 subjects were girls were tested using the Lea Symbols chart and the Sheridan Gardiner chart. The mean a...

This paper introduces a new class of processor interconnection topology called LEA (Linearly Extendable ARM). The attractive properties of LEA topology include constant degree, moderate diameter, regularity, symmetry, scalability and simple routing. LEA, when used as one of the components of an interconnection topology based on product graphs, is capable of maintaining the constant degree over ...