Discussion Papers are a series of manuscripts in their draft form. They are not intended for circulation or distribution except as indicated by the author. For that reason Discussion Papers may not be reproduced or distributed without the written consent of the author. Abstract Despite the airport privatization and deregulation trend in recent years, whether or not the privatized or commerciali...

This study aimed to investigate the impact of methylxanthine abstinence (MA) periods on CYP1A2 activity in individuals with varying levels of caffeine consumption through development of a population pharmacokinetic model of caffeine and its major metabolite paraxanthine. This study developed and evaluated a mixed-effects pharmacokinetic model for caffeine and paraxanthine concentration-time dat...

This study aimed to investigate the impact of methylxanthine abstinence (MA) periods on CYP1A2 activity in individuals with varying levels of caffeine consumption through development of a population pharmacokinetic model of caffeine and its major metabolite paraxanthine. This study developed and evaluated a mixed-effects pharmacokinetic model for caffeine and paraxanthine concentration-time dat...

It is not clear how many L-type Ca channels (LCCs) are required to ensure that a Ca spark is triggered during a normal mammalian action potential (AP). We investigated this in rabbit ventricular myocytes by examining both the properties of sparks evoked by APs and the activity of LCCs. We measured Ca sparks evoked by repeated APs with pipettes containing 2 mmol/L EGTA and single LCC activity in...

It is not clear how many L-type Ca channels (LCCs) are required to ensure that a Ca spark is triggered during a normal mammalian action potential (AP). We investigated this in rabbit ventricular myocytes by examining both the properties of sparks evoked by APs and the activity of LCCs. We measured Ca sparks evoked by repeated APs with pipettes containing 2 mmol/L EGTA and single LCC activity in...

In cardiac ventricular myocytes, calcium (Ca) release occurs at distinct structures (dyads) along t-tubules, where L-type Ca channels (LCCs) appose sarcoplasmic reticulum (SR) Ca release channels (RyR2s). We developed a model of the cardiac ventricular myocyte that simulates local stochastic Ca release processes. At the local Ca release level, the model reproduces Ca spark properties. At the wh...

Introduction: Improving the temporal constraints of Martian geologic processes is essential for understanding the formational history of the planet and providing adequate context for exploration. Martian surfaces are generally delineated into discrete packages based on morphological, compositional, and/or temporal characteristics, the latter of which are derived through (1) apparent cross-cutti...

Cardiac excitation-Ca2+ release coupling is, in essence, a tale of two molecules, sarcolemmal voltage-gated L-type Ca2+ channels (LCCs) and intracellular ryanodine receptors (RyRs), communicating via the Ca2+-induced Ca2+ release mechanism. Recent advances have provided a microscopic view of the intermolecular Ca2+ signaling between LCCs and RyRs. In a dyadic junction or a "couplon", LCCs open ...

We study questions in incidence geometry where the precise position of points is ‘blurry’ (e.g. due to noise, inaccuracy or error). Thus lines are replaced by narrow tubes, and more generally affine subspaces are replaced by their small neighborhood. We show that the presence of a sufficiently large number of approximately collinear triples in a set of points in C implies that the points are cl...