es, such as α-mannosidases (MAN) and β-galactosidases (GAL), are found in different glycoside hydrolase sequencebased families. Considerable research has proved plays the role of MAN, which play a key role in the modification and diversification of hybrid N-glycans, processes with strong cellular links to cancer. Therefore the study aim was to investigate the activities of MAN and GAL in larynx...

Laryngeal squamous cell carcinoma is very common in head and neck cancer, with high mortality rates and poor prognosis. In this study, we compared expression profiles of clinical samples from 13 larynx tumors and 10 non-neoplastic larynx tissues using a custom-built cDNA microarray containing 331 probes for 284 genes previously identified by informatics analysis of EST databases as markers of h...

OBJECTIVES/HYPOTHESIS To develop and validate a simple prognostic tool that would help predict larynx preservation outcome. STUDY DESIGN A retrospective review of 3 prospective studies. METHODS We reviewed consecutive chemotherapy/radiation protocols for patients (n = 170) with advanced, resectable, squamous cell, larynx, or pharynx cancer treated at Memorial Sloan-Kettering Cancer Center f...

Glutathione S-transferase (GST) isoenzymes are involved in the detoxification of several tobacco smoke-derived carcinogens. It is thus conceivable that deficiency in GST activity due to homozygous deletion of the GSTM1 and GSTT1 genes (the null genotypes) may modulate susceptibility to smoking-induced cancers. The effects of the GSTM1 and GSTT1 null genotypes on laryngeal cancer risk were evalu...

A previous study indicated that MLL3 genetic polymorphisms were associated with human cancer. However, whether MLL3 genetic variants are associated with the risk of laryngeal cancer is not clear. This study investigated the association between MLL3 gene polymorphisms and laryngeal cancer in a Chinese population. Four polymorphisms of the MLL3 gene (rs6943984, rs4725443, rs3800836, rs6464211) we...

PURPOSE The mechanism of larynx oncogenesis is complex and controlled by various factors, most of them involved in cell proliferation and apoptosis. In this study, we evaluated the levels of two suppressor proteins (pRb and p53) and two oncogenic proteins (c-Myc and Bcl-2), as well as the apoptotic levels and the presence of human papillomavirus (HPV) in both tumor types. EXPERIMENTAL DESIGN ...

Head and Neck Cancer (HNC) is a broad category of cancer, comprises cancer that origin into oral cavity, pharynx, larynx, sinuses salivary gland. Majority cases reported in Pakistan are metastatic to with morphology squamous cell carcinoma. Locally advance, un-resectable tumors treated systemic therapies. Commonly prescribe therapies includes chemotherapy targeted therapy. However, the most pre...

Introduction . In the last decades, a discernable trend towards more frequent use of endoscopic laser surgery in operative treatment cancer middle part larynx is observed. Smaller trauma, absence tracheostomy, short hospitalization time, and better functional outcomes without compromising oncological are significant reasons for transition to methods. However, local recurrence involving anterior...