AIMS Angiogenesis and vessel organisation in laryngeal tumour development and progression were examined to determine characteristics of biological and clinical relevance. METHODS Automated quantitative image analysis was performed on 1451 factor VIII (FVIII) associated blood vessels with regard to occurrence, structure, size, shape, and staining intensity, in addition to vessel direction. R...

Numerous diseases that require surgical treatment often occur in the thyroid, one of the most important organs in the neck. An example of such pathologies are benign and malignant neoplasms. It is still not well known, however, if certain secondary malignant neoplasms may also arise there. While this pathology is relatively frequent, and often asymptomatic, the incidence of secondary lesions ob...

OBJECTIVE Cancer remains a crucial problem of contemporary medicine and the principle is perfectly true regarding the laryngeal cancer. Laryngologists are constantly searching for laryngeal cancer to provide functional and oncological surgical techniques. Conservative surgery in laryngeal cancer tries to keep enough laryngeal lumen and maintain the main laryngeal functions: breath, phonation, s...

BACKGROUND Sarcomas of the larynx are rare neoplasms that constitute less than 1% of laryngeal malignancies. A Medline search found no large series focusing on laryngeal sarcomas. We reviewed the cases of laryngeal sarcomas treated in our cancer center and compared our experiences and treatment results with those from other centers. METHODS A retrospective review of 10 patients with laryngeal...

Paragangliomas are rare benign neoplasms arising from the neural crest-derived paraganglia of the autonomic nervous system. In the larynx three different localizations of paraganglia are known. Most laryngeal paragangliomas arise from the supraglottic paraganglia. A review of the literature shows that the treatment of choice for laryngeal paragangliomas is surgical excision. Since the implement...

BACKGROUND The immunoglobulin heavy chain binding protein (BiP)/glucose-regulated protein 78 (GRP78) is important in the endoplasmic reticulum stress, and is highly expressed in various human cancers. The clinical and pathological features of GRP78/BiP are unclear in patients with advanced laryngeal squamous cell carcinoma (SCC). The purpose of this study was to investigate the clinicopathologi...

This study analysed the immunohistochemical expression of the CAF-1/p60 protein in laryngeal cancers. CAF-1/p60 assumes an independent discriminative and prognostic value in laryngeal neoplasms; the presence of this protein in carcinoma in situ compared with laryngeal precancerous and larynx infiltrating tumours. We assessed the immunohistochemical expression of CAF-1/p60 in 30 cases of moderat...

Ewing sarcomas (EWS) are highly malignant neoplasms of mesenchymal origin that rare in the head and neck. Only a few laryngeal EWS have been reported literature. We report 47 years-old man who visited our hospital for medical help after 5 months hoarseness sore throat. Computed tomography (CT) showed uneven thickening epiglottis fold, right vocal cord, anterior union. In addition, fluoro-18-flu...