We aimed to measure the invasion ability of Hep-2 laryngeal cancer cells after treatment with C-erbB-2-small interfering RNA (siRNA)-chitosan nanoparticles, and assess the applied value of chitosan nanoparticle-mediated C-erbB-2 interference in inhibiting laryngeal cancer invasion and metastasis. Nanoparticles of approximately 100 nm, comprising C-erbB-2 siRNA packaged with chitosan, were prepa...

Laryngeal cancer is one of the most commonly occurring malignant cancers of the head and neck region. In the present study, we investigated the roles of miR-221 in laryngeal squamous cell carcinoma cell line, Hep-2. We examined the function and mechanism of miR-221 in Hep-2 cells using techniques of cell biology and molecular pathology, such as western blotting, quantitative PCR, immunohistoche...

The differences in phonation between men and women are thought to occur from anatomical differences in the larynx. However, it is not known if there are any differences in cough dynamics between the sexes. We investigated this by asking 100 healthy, non-smoking adults (50 male) to perform a voluntary cough into a tussometer. Each volunteer coughed at four different lung volumes, ranging from to...

Phonation was induced in 10 mongrel dogs under general anesthesia by way of transtracheal stimulation of the recurrent laryngeal nerves under conditions of constant air flow. Although stimulation voltages were approximately 10 times the voltage required for direct stimulation, no cardiac or respiratory abnormalities were observed. Photoglottographic and electroglottographic signals were the sam...

 Background: Focal laryngeal candidiasis is not reported widely and is very infrequently recognized clinically. This disease is rare and may occur after pulmonary, pharyngeal and esophageal candidiasis or as part of disseminated disease. It is also secondary to inhaled steroid therapy which is usually mild and has been reported in 10-15 percent of patients taking these medications.  Case Pr...

OBJECTIVES/HYPOTHESIS This study aimed to investigate and measure airway dynamics in anatomical regions where laryngeal cancer was most common in comparison to other regions of the larynx, thereby determining the effect of airway dynamics on the development of laryngeal cancer. STUDY DESIGN AND METHODS Pulmonary function test airflow data and larynx anatomy measurement data obtained by three-...

The hypothesis that upper airway (UA) pressure and flow modulate respiratory muscle activity in a respiratory phase-specific fashion was assessed in anesthetized, tracheotomized, spontaneously breathing piglets. We generated negative pressure and inspiratory flow in phase with tracheal inspiration or positive pressure and expiratory flow in phase with tracheal expiration in the isolated UA. Sti...

One third of adults experience laryngeal symptoms such as throat clearing and chronic cough 50-80% seeking care these are told that laryngopharyngeal reflux (LPR) is the etiology. LPR results from retrograde flow gastroduodenal contents to larynx pharynx; however, treatment presumed remains challenging with limited evidence-based guidance. This article summarizes @GIJournal Twitter discussion Y...

Human esophageal cancer‑related gene 4 (ECRG4) is a potential tumor suppressor gene isolated from human esophageal epithelial cells. Studies have shown that ECRG4 effectively inhibits the proliferation of tumor cells and induces apoptosis. However, the role of ECRG4 in laryngeal cancer has not yet been clearly defined. In this study, a human laryngeal cancer cell line stably overexpressing ECRG...