Larsen syndrome is characterized by multiple joint dislocations, associated with a typical facial appearance and frequently other abnormalities. Both dominant and recessive patterns of inheritance have been reported. A lethal form of Larsen syndrome (Larsen-like syndrome) has been described as a combination of the Larsen phenotype and pulmonary hypoplasia. In this report, we present a 24-week-o...

The collapses of the Larsen A and B ice shelves on the Antarctic Peninsula in 1995 and 2002 confirm the impact of southward-propagating climate warming in this region. Recent mass and dynamic changes of Larsen B's southern neighbour Larsen C, the fourth largest ice shelf in Antarctica, may herald a similar instability. Here, using a validated ice-shelf model run in diagnostic mode, constrained ...

OBJECTIVE To determine immunohistological markers in synovial tissue of patients with early rheumatoid arthritis (RA) which are associated with unfavourable disease outcome. METHODS Synovial tissue was obtained from 36 patients with RA within 1 year after the initial symptoms and before starting disease modifying antirheumatic drug treatment. Clinical, laboratory, and radiological assessments...

Objective: To determine immunohistological markers in synovial tissue of patients with early rheumatoid arthritis (RA) which are associated with unfavourable disease outcome. Methods: Synovial tissue was obtained from 36 patients with RA within 1 year after the initial symptoms and before starting disease modifying antirheumatic drug treatment. Clinical, laboratory, and radiological assessments...

introduction: rheumatoid arthritis (ra) is the most common autoimmune joint disease. osteoporosis is a well-known consequence of ra. objective: the aim of the present study was to determine the interrelationship between radiographic findings and bone mineral density (bmd) in patients with ra. methods: 70 patients with established ra (according to 1987 acr criteria) were included in a cross-sect...

INTRODUCTION Disease activity, severity and comorbidity contribute to increased mortality in patients with rheumatoid arthritis (RA). We evaluated the impact of age at disease onset on prognostic risk factors and treatment in patients with early disease. METHODS In this study, 950 RA patients were followed regularly from the time of inclusion (<12 months from symptom onset) for disease activi...

BACKGROUND Periarticular osteopenia is an early sign of incipient joint injury in rheumatoid arthritis (RA), but cannot be accurately quantified using conventional radiography. Digital X-ray radiogrammetry (DXR) is a computerized technique to estimate bone mineral density (BMD) from hand radiographs. The aim of this study was to evaluate whether decrease in BMD of the hands (BMD loss), as deter...