نتایج جستجو برای: large genomic rearrangements

تعداد نتایج: 1142013  

2017
Özlem Barış Mehmet Karadayı Derya Yanmış Medine Güllüce

Journal: :DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes 2008
Mariko Naito Hideki Hirakawa Atsushi Yamashita Naoya Ohara Mikio Shoji Hideharu Yukitake Keisuke Nakayama Hidehiro Toh Fuminobu Yoshimura Satoru Kuhara Masahira Hattori Tetsuya Hayashi Koji Nakayama

The gram-negative anaerobic bacterium Porphyromonas gingivalis is a major causative agent of chronic periodontitis. Porphyromonas gingivalis strains have been classified into virulent and less-virulent strains by mouse subcutaneous soft tissue abscess model analysis. Here, we present the whole genome sequence of P. gingivalis ATCC 33277, which is classified as a less-virulent strain. We identif...

Journal: :Cancer genetics and cytogenetics 2006
Sabine Preisler-Adams Ines Schönbuchner Britta Fiebig Brigitte Welling Bernd Dworniczak Bernhard H F Weber

A total of 226 index cases from high-risk hereditary breast and ovarian cancer families of German origin who had tested negative for small nucleotide alterations in BRCA1 and BRCA2 were analyzed for gross genomic rearrangements at the two gene loci by the multiplex ligation-dependent probe amplification technique. Six large genomic alterations were identified in BRCA1, while no gross rearrangem...

Journal: :journal of medical microbiology and infectious diseases 0
noushin lotfi mashhad, iran maryam rastin mashhad, iran parisa shoaei isfahan,iran bahram memar mashhad, iran nafiseh sadat tabasi mashhad, iran zohreh mahmoudi mashhad, iran

introduction: most b-cell malignancies are diagnosed based on morphologic and immunohistochemical criteria. some cases, however, still present a challenge for the pathologist to discriminate between reactive hyperplasia and neoplastic disorders. molecular techniques can be used as a helpful diagnostic tool in these cases. in this study, we assessed the value of polymerase chain reaction (pcr) t...

Journal: :PathoGenetics 2008
Wenli Gu Feng Zhang James R Lupski

Genomic rearrangements describe gross DNA changes of the size ranging from a couple of hundred base pairs, the size of an average exon, to megabases (Mb). When greater than 3 to 5 Mb, such changes are usually visible microscopically by chromosome studies. Human diseases that result from genomic rearrangements have been called genomic disorders. Three major mechanisms have been proposed for geno...

2017
Weerachai Jaratlerdsiri Eva K.F. Chan Desiree C. Petersen Claire Yang Peter I. Croucher M.S. Riana Bornman Palak Sheth Vanessa M. Hayes

Complex genomic rearrangements are common molecular events driving prostate carcinogenesis. Clinical significance, however, has yet to be fully elucidated. Detecting the full range and subtypes of large structural variants (SVs), greater than one kilobase in length, is challenging using clinically feasible next generation sequencing (NGS) technologies. Next generation mapping (NGM) is a new tec...

Journal: :Genes & development 2014
Ranjith P Anand Olga Tsaponina Patricia W Greenwell Cheng-Sheng Lee Wei Du Thomas D Petes James E Haber

Recent high-resolution genome analyses of cancer and other diseases have revealed the occurrence of microhomology-mediated chromosome rearrangements and copy number changes. Although some of these rearrangements appear to involve nonhomologous end-joining, many must have involved mechanisms requiring new DNA synthesis. Models such as microhomology-mediated break-induced replication (MM-BIR) hav...

Journal: :Genome dynamics 2006
P Stankiewicz J R Lupski

In the past fifteen years, an emerging group of genetic diseases have been described that result from DNA rearrangements rather than from single nucleotide changes. Such conditions have been referred to as genomic disorders. The predominant molecular mechanism underlying the rearrangements that cause this group of diseases and traits is nonallelic homologous recombination (NAHR) (unequal crossi...

2007
Christoph Dieterich

Motivation Other more recent applications include: • Comparative genomic hybridization (Array CGH) Assessing large genomic rearrangements. • SNP detection arrays Looking for Single nucleotide polymorphism in the genome of populations. • Chromatin immunoprecipitation (ChIP) studies Determining protein binding site occupancy throughout the genome. Whole-genome tilting arrays are mostly used for t...

Journal: :Journal of bacteriology 1999
S Stibitz M S Yang

We determined the genomic organization of 14 clinical strains of Bordetella pertussis isolated over an 18-month period in Alberta, Canada. The maps of these 14 strains, while demonstrating general similarity of gene order, display a number of examples of genomic rearrangements in the form of large chromosomal inversions.

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