Regulatory T cells (Tregs) play an important role in the maintenance of peripheral tolerance. Several molecules including TGF-beta have been linked to the function and differentiation of Tregs. In this study, we describe a unique population of T cells expressing a membrane bound form of TGF-beta, the latency-associated peptide (LAP), and having regulatory properties in human peripheral blood. T...

Bi, PASQUALE E. PEIIILLIE T HE ALKALINE PHOSPHATASE ACTIVITY of the granulocytes (LAP) in patients with chronic granulocytic leukemia (CGL) usually is not increased following stimulation by either adrenocortical hormones or pyrogen, whereas the LAP of normal subjects and most patients with nonleukemic disorders shows a definite rise following similar stimulation. ’ An occasional patient with we...

OBJECTIVES To compare the cost-effectiveness and morbidity of minilaparotomy (MINILAP) and laparoscopic pelvic lymphadenectomy (LAP) in a community practice setting. METHODS We reviewed our experience with 44 consecutive patients with prostate cancer who had staging pelvic lymphadenectomy from January 1992 through April 1995 in a general health maintenance organization urology practice. Of th...

PURPOSE Oxytocin (OT) was reported to inhibit the proliferation of various neoplastic tissues and cells, however, the regulation system remains unclear. This study examined the role of OT and its regulatory ability in endometrial adenocarcinoma. EXPERIMENTAL DESIGN To investigate the possible function of placental leucine aminopeptidase (P-LAP) in endometrial adenocarcinoma, we transfected P-...

The potential of different parasite proteinases for use as vaccine candidates against fascioliasis in sheep was studied by vaccinating animals with the cathepsin L proteinases CL1 and CL2 and with leucine aminopeptidase (LAP) purified from adult flukes. In the first trial, sheep were immunized with CL1 or CL2 and the mean protection levels obtained were 33 and 34%, respectively. Furthermore, a ...

Non-invasive and immediate estimation of left atrial pressure (LAP) is very useful for the management of mitral regurgitation (MR), and many reports have assessed echocardiographic estimations of LAP to date. However, it has been unclear of which examination and evaluate article possess the best accuracy for the MR severity. The present research aims to establish the echocardiographic estimatio...

PURPOSE Suppressor T cells are one of the determinants of colorectal cancer (CRC) clinical outcome. LAP(+)CD4(+) T cell is a recently identified subset of suppressor T cells. This study was designed to investigate their clinical relevance in patients with CRC. EXPERIMENTAL DESIGN Sixty patients with CRC and 24 healthy donors (HD) were enrolled in this study. The percentages of LAP(+)CD4(+) T ...

The main purpose of this study was to analyze tactical solutions used by swimmers, the finalists of the 19th Beijing Olympics in 2008, in individual front crawl events at distances of 50, 100 and 200 m. Observations were carried out on 7 swimmers, the Beijing Olympics medalists competing in front crawl individual events. Detailed analyses were run on: 1) Sports results obtained by the finalists...

Despite offering several promising concepts, the Language/Action Perspective (LAP) is still not in the mainstream of Information Systems Development (ISD). With use of a comparative evaluation of LAP theory and DEMO theory, the implication of DEMO’s reflection upon LAP is determined. The paper concludes by outlining an agenda for further research if LAP is to improve its footprint in the field.

BACKGROUND β-Lapachone (β-lap) is a bioreductive agent that is activated by the two-electron reductase NAD(P)H quinone oxidoreductase 1 (NQO1). Although β-lap has been reported to induce apoptosis in various cancer types in an NQO1-dependent manner, the signaling pathways by which β-lap causes apoptosis are poorly understood. METHODOLOGY/PRINCIPAL FINDINGS β-Lap-induced apoptosis and related ...