cytokine production  in response to allergens may influence the development of atopy- predisposing immune responses, initializing the  early programming of  allergy and  asthma. vitamin d  intake  may be  protective  due  to  its  immunoregulatory properties,  that  may contribute  to  influence the expression of  the atopic phenotype  initiated in early life. the objective of our study was to ...

BACKGROUND Allergy to cow's milk protein (CMP) may cause gastrointestinal (GI) symptoms in the absence of CMP specific IgE. The immunological mechanisms involved in such disease are not fully understood. Therefore we examined markers of gut mucosal inflammation and the immunoglobulin profiles in children with Gl symptoms suspected of cow's milk protein allergy (CMPA). PATIENTS AND METHODS We ...

The interactions of β-lactoglobulin AB in the presence of cationic surfactants such as Cetyltrimethylammonium bromide and Cetyltrimethylammonium p-Toluenesulfonate have been investigated using a variety of experimental techniques such as conductivity, UV-Vis spectrophotometry and fluorimetry. The conductivity of surfactants aqueous solutions with β-lactoglobulin shows that the cmc of cationic s...

Infants born to atopic parents have been found to be at high risk of allergy development. The present study investigated the effect of a maternal milk-free diet during late pregnancy and lactation on the immune response and allergy incidence in at-risk and control infants. Atopic mothers were randomly allocated into an intervention group (n 12) or an unrestricted-diet group (n14) and compared w...

Abstract Oil in water emulsions are commonly stabilized by emulsifying constituents like proteins and/or low molecular weight emulsifiers. The can compete or coexist at the interface. Interfacial properties thus depend on structure of and oil phase resulting interactions. present study systematically analyzed impact fatty acid saturation triacylglycerides phosphatidylcholine interfacial a β-lac...

Aggregation of beta-lactoglobulin occurs mainly via intermolecular disulphide bond exchange. Upon heating, beta-lactoglobulin aggregated which increased with increasing pH. The presence of DTT led to more rapid aggregation and precipitation of beta-lactoglobulin. AlphaCrystallin prevented the aggregation of heat-stressed beta-lactoglobulin and was a more efficient chaperone at higher pH values....

AIM To determine whether oral administration of Bifidobacterium infantis CGMCC313-2 (B. infantis CGMCC313-2) inhibits allergen-induced airway inflammation and food allergies in a mouse model. METHODS Ovalbumin (OVA)-induced allergic asthma and β-lactoglobulin-induced food allergy mouse models were used in this study. Following oral administration of B. infantis CGMCC313-2 during or after alle...

BACKGROUND Thymic stromal lymphopoietin (TSLP) is involved in the pathogenesis of allergic reactions in the skin and the lung. Nevertheless, data on the role of TSLP in food allergy are scarce. We explored the role of TSLP in a mouse model with oral sensitization and oral challenge eliciting food allergy. METHODS TSLP receptor (TSLPR)-/- mice and wild type mice were orally sensitized to β-lac...

OBJECTIVE This study aimed to evaluate the adverse effects of extensively hydrolyzed milk formula on growth in infants and toddlers. METHODS Prospectively, 45 infants and toddlers with a positive history of cow's milk allergy confirmed by positive skin prick test and high IgE levels for either alpha-lactalbumin, beta-lactoglobulin, or casein and positive single-blind food challenge received e...

Hypoallergenic formulas containing hydrolyzed protein are intended for use by infants to prevent cow’s milk allergy. The degree of hydrolysis epitopic areas determines the residual allergenicity whey hydrolysates (WPHs). However, only amino-acid-based infant (IFs) considered entirely nonallergenic. aim this study was investigate four commercially available WPHs with different (H1–H4) potential ...