BACKGROUND In this observational study near infrared spectroscopy (NIRS) was evaluated as a non-invasive monitor of impaired tissue oxygenation (StO2) after cardiac surgery. StO2, cardiac output, mixed venous oxygen saturation and mean arterial pressure were compared with lactate clearance as established measure for sufficient tissue perfusion and oxygen metabolism. METHODS Forty patients aft...

INTRODUCTION Hyperlactatemia represents one prominent component of the metabolic response to sepsis. In critically ill patients, hyperlactatemia is related to the severity of the underlying condition. Both an increased production and a decreased utilization and clearance might be involved in this process, but their relative contribution remains unknown. The present study aimed at assessing syst...

the aim of this study was to assess the effects of intermittent training on lactate level and lactate dehydrogenase enzyme activity in wistar rats. 20 male wistar rats (mean age 3 months and weight 224±14 g) were selected and randomly divided into the training (n=10) and control (n=10) groups. the training protocol consisted of running on a treadmill for 4 minutes and then 2 minutes of active r...

Glucose-fructose ingestion increases glucose and lactate oxidation during exercise. We hypothesized that training with glucose-fructose would induce key adaptations in lactate metabolism. Two groups of eight sedentary males were endurance-trained for three weeks while ingesting either glucose-fructose (GF) or water (C). Effects of glucose-fructose on lactate appearance, oxidation, and clearance...

1162 December 2012 W HEN oxygen delivery falls below a critical threshold, the anaerobic threshold, the amount of oxygen available for consumption is not able to meet the needs of cells. These imbalances result in cellular hypoxia, resulting in the failure of mitochondrial oxidative phosphorylation, and as a result energy metabolism becomes wholly dependent on anaerobic glycolysis.1 Anaerobic g...

lactate acid, skeletal muscle, mortality Lactic acid is a naturally occurring molecule with original detection falling into a category of lactic acid-producing bacterial organisms. However first detected in foods, its increased concentration in muscles of hunted animals was later linked with lactate acidosis origin. Physiologically, high rate of ATP hydrolysis, occurring during anaerobic glycol...

We evaluated the hypotheses that endurance training decreases arterial lactate concentration ([lactate](a)) during continuous exercise by decreasing net lactate release () and appearance rates (R(a)) and increasing metabolic clearance rate (MCR). Measurements were made at two intensities before [45 and 65% peak O(2) consumption (VO(2 peak))] and after training [65% pretraining VO(2 peak), same ...