The expression and functional role of ether-à-go-go-related gene (erg) K+ channels were examined in the bovine epididymal duct. Sperm transit through the epididymal duct relies on spontaneous phasic contractions (SC) of the peritubular smooth muscle wall. Isometric tension studies revealed SC-enhancing effects of the erg channel blockers E-4031, dofetilide, cisapride, and haloperidol and SC-sup...

NS1643 is one of the small molecule HERG (Kv11.1) channel activators and has also been found to increase erg2 (Kv11.2) currents. We now investigated whether NS1643 is also able to act as an activator of Kv11.3 (erg3) channels expressed in CHO cells. Activation of rat Kv11.3 current occurred in a dose-dependent manner and maximal current increasing effects were obtained with 10 µM NS1643. At thi...

Noble metallic nanostructures with strong electric near-field enhancement can significantly improve nanoscale light–matter interactions and are critical for high-sensitivity surface-enhanced Raman spectroscopy (SERS). Here, we use an azimuthal vector beam (AVB) to illuminate the plasmonic tips circular cluster (PTCC) array enhance intensity of PTCC array, then it SERS sensitivity. The was prepa...

OBJECTIVE The clavulanic acid regulatory gene (claR) is in the clavulanic acid biosynthetic gene cluster that encodes ClaR. This protein is a putative regulator of the late steps of clavulanic acid biosynthesis. The aim of this research is the molecular cloning of claR, isolated from the Iranian strain of Streptomyces clavuligerus (S. clavuligerus). MATERIALS AND METHODS In this experimental ...

Hole U1309A: Latitude: 30° 10.1081' N, Longitude: 42° 07.1101' W, 1643 mbsl Hole U1309B: Latitude: 30° 10.1081' N, Longitude: 42° 07.1101' W, 1643 mbsl Hole U1309C: Latitude: 30° 10.1081' N, Longitude: 42° 07.1209' W, 1638 mbsl Hole U1309D: Latitude: 30° 10.1195' N, Longitude: 42° 07.1131' W, 1645 mbsl Hole U1309E: Latitude: 30° 10.1207' N, Longitude: 42° 07.1057' W, 1644 mbsl Hole U1309F: Lati...