Collaborative design, i.e., design involving the participation of multiple specialists, is an inherently COml)lex activity. It can benefit greatly from computer-based pTvccss support in which the emphasis is oil addressing the generic needs of decision-making processes [Raggl]. I)roccss support as (h’fim’d in [Rag91] includes: SUl)l)orting tim i)lam~ing, organization, and ext’cution of complex ...

Line-active molecules (‘‘linactants’’) that bind to the boundary interface between different fluid lipid domains in membranes have a strong potential as regulators of the lateral heterogeneity that is important for many biological processes. Here, we use molecular dynamics simulations in combination with a coarse-grain model that retains near-atomic resolution to identify lipid species that can...

BACKGROUND Osteoarthritis (OA) is one of the most common causes of pain and disability in the adult population. Several studies have documented discordance between general practioners (GP) practice and management recommendations, but there is limited published information about patient reported experience of quality of care. The primary aim of this study was to assess the patient perceived qual...

A malignant basal cell tumor was found in the skin of the abdornen of a female Djungarian hamster of unknown age and weighing 40 g. Histologically. the tumor mass was composed ef cells resembling the basal cells of the epiderrnis, and these cells exhibited solid type preliferation. In the tumor tissue and necrotic foci, horn cysts were observed. Irnrnunohistochemically. cytokeratin was present ...

The dopaminergic receptor D1 activates and the muscarinic acetylcholine receptor (mAChR) M4 inhibits adenylyl cyclase (AC) and thereby cAMP production through the trimeric Gas and Gai/o proteins, respectively (Wess et al, 2007). D1 and M4 are coexpressed in striatal output neurons, where M4 antagonizes D1 signalling as recently pinpointed by conditional M4 knockout in D1-expressing neurons (Jeo...

Six naturally occurring and three synthetic molecubetween the molecular species composition of those glylar species of lactosylceramide (Laccer) were used to examine cosphingolipids with more complex carbohydrate chains the molecular species specificity of CMP-N-acetylneuramiand their simpler (shorter carbohydrate chain) glyconate:lactosylceramide a2,3-sialyltransferase in a Golgi-rich fracsphi...

A recently introduced algorithm for solving the inverse problem for simple classical fluids (i.e. the deduction of the interatomic interaction from structural data), which is based on the fundamental-measure free-energy density functional for hard spheres, is analysed in comparison with other methods. In a benchmark test for the Lennard-Jones system near the triple point, it is comparable with ...

In recent years, several studies have demonstrated that different ligands can have distinct efficacy profiles toward various signaling pathways through a unique receptor. For example, 1-adrenergic compounds that are inverse agonists toward the adenylyl cyclase (AC) can display agonist activity for the mitogen-activated protein kinase (MAPK) pathway. Such a phenomenon, often termed functional se...