Central sensitization, the hyperexcitability of spinal processing that often accompanies peripheral injury, is a major component of many persistent pain states. Here we report that the neurotrophin, brain-derived neurotrophic factor (BDNF), is a modulator of excitability within the spinal cord and contributes to the mechanism of central sensitization. BDNF, localized in primary sensory neuron c...

Vanilloid receptor type 1 (VR1) (TRPV1) is a ligand-gated ion channel expressed on sensory nerves that responds to noxious heat, protons, and chemical stimuli such as capsaicin. Herein, we have examined the activity of the VR1 antagonist capsazepine in models of inflammatory and neuropathic pain in the rat, mouse, and guinea pig. In naïve animals, subcutaneous administration of capsazepine (10-...

Expression of parvalbumin (PV) and transient receptor potential vanilloid (TRPV1) receptors in the lumbar dorsal root ganglion neurons (DRG) was evaluated in control animals and in rats after acute carageenan-induced knee joint inflammation. PV is a calcium binding protein that acts as a calcium buffer, affects intracellular calcium homeostasis and may thus influence signal transduction and syn...

background this study investigated the anti-inflammatory effect of fumaria parviflora due to its fumaric acid, flavonoid and phenolic compounds for skin diseases, relieves itching and eczema. material and methods male wistar rats (ranging 150-180g in weight) were used. for preparation of the hydro alcoholic extract, plant powdered were macerated in ethanol 70%, then extract were concentrated fo...

15 evaluate the correction term for each triple in the left side of table 1, but for brevity of exposition we will evaluate this term only for a sample of each class (T 2 and T 4).

In the present study, azothioprine, chloroquine, D-penicillamine, methotrexate and sodium aurothiomalate (gold salt) were evaluated for possible disease-modifying effects in the adjuvant-induced arthritis model of human rheumatoid arthritis in rats. Gait analysis was used to examine the role of disease-modifying antirheumatic drugs in the development of pain. Body weights were also measured to ...

The double lepton pair decay modes of the KL meson are analyzed including all contributions of order p in Chiral Perturbation Theory. The experimentally established eeee mode and the recently observed eeμμ mode are discussed in detail. Typeset using REVTEX 0 In this note we reconsider the double lepton pair decays KL → llll that were studied many years ago by Miyazaki and Takasugi [1]. The two ...

The biological diversity of the immune system is reflected in the variety of immune effector systems and mediation pathways that have emerged. Among the least recognized involve the hemostatic pathways. The possibility of cellular and molecular linkages between two host defense mechanisms, the hemostatic and immune systems, has long been suggested, but has yet to be satisfactorily delineated. T...

in this research, the effect of different levels of carrageenan gum (0.05– 0.2%) and whey protein concentrate (0.5 - 1.5%) on physical, chemical and sensory properties of low fat mozzarella cheese have been investigated. use of these fat replacers cause significant differences (p ≤ 0.05) on chemical properties as increase in gum and wpc resulted moisture and protein content to increase but ph t...