Ginkgolides (GG), containing ginkgolide A (GA), ginkgolide B (GB) and ginkgolide C (GC), are mainly prescribed for ischemic stroke and cerebral infarction. However, the ginkgolides can hardly pass the blood-brain barrier (BBB) into the brain. The purpose of this study was to prepare borneol-modified ginkgolides liposomes (GGB-LPs) to study whether borneol could enhance the transport of ginkgoli...

Borneol and menthol were two terpenes wildly used as penetrate enhancer in 14 transdermal drug delivery. To explore their penetration enhancement effect towards hydrophilic 15 drug, 5-FU was selected as model drug. A method combined vitro permeation studies and coarse 16 grain molecular dynamics was used to investigate their penetration enhancement effect towards 17 5-FU. As a result, although ...

The relative proportions of chemical classes (hydrocarbons, oxides, alcohols, ketones, esters) in the essential oil of rosemary (Rosmarinus officinalis L., Lamicaeae) and in the volatile fraction of the infusion extracts were examined and showed remarkable differences.The volatile compounds of the infusion were isolated by two different methods, hydrodistillation and solid phase extraction (SPE...

Thymus hyemalis L. and Spanish T. vulgaris subsp. vulgaris shrubs are characterized by a great chemical intraspecific variability among plants. This fact makes it difficult to detect real changes occurring in their essential oil composition during the vegetative cycle. Because of this, clones of T. hyemalis and T. vulgaris were used to monitor seasonal variations in their aromatic composition o...

Novel disulfinyl derivatives based on 3,4-dichloro-2(5H)-furanone, aliphatic dithiols, and monoterpene alcohols were synthesized. Chiral bis-thioethers in the molecules of which dithiol fragment links two five-membered cycles at C4 atoms obtained reactions 5(S)-(l-menthyloxy)- 5(S)-(l-bornyloxy)-2(5H)-furanones with ethane-1,2-dithiol propane-1,3-dithiol acetone basic medium. The action an exce...

The essential oil obtained by steam distillation of dried aerial parts of Ambrosia trifida L. from Northeast China was analyzed by GC and GC-MS. The essential oil yield based on dried plant material was 0.12% and thirty-five compounds (corresponding to 86.7% of the total weight) were identified. The main components were: bornyl acetate (15.5%), borneol (8.5%), caryophyllene oxide (8.3%), alpha-...

CONTEXT The destabilization of β-amyloid (Aβ) peptide aggregates and the protection of functional cells are the attractive therapeutic strategies for Alzheimer's disease (AD). Some active ingredients of Salvia miltiorrhiza f. alba C.Y.Wu & H.W.Li (Lamiaceae) (SM) have attracted increasing attention for the treatment of neurodegenerative diseases. OBJECTIVE Salvianic borneol ester (SBE) is a n...

The essence oil from the fresh rhizomes of Kaempferia rotunda L. was isolated by water distillation and analyzed by gas chromatography-mass spectrometry (GC/MS) method. Fifty seven components were identified in the rhizomes oil, which accounted to 99.74% of the oil. The major components were endo-borneol (9.30%), dehydro iso androsterone acetate (9.12%), naphthalene, decahydro-1,1,4a-trimethyl-...