نتایج جستجو برای: ku

تعداد نتایج: 7189  

Journal: :Journal of radiation research 2002
Manabu Koike

The Ku protein is a complex of two subunits, Ku70 and Ku80, and was originally identified as an autoantigen recognized by the sera of patients with autoimmune diseases. The Ku protein plays a key role in multiple nuclear processes, e.g., DNA repair, chromosome maintenance, transcription regulation, and V(D)J recombination. The mechanism underlying the regulation of all the diverse functions of ...

2015
Conrado Martins Alfredo Alves Neto Fabio Kuschnir José Luiz De Magalhães Rios Marilucia Alves Da Venda João Bosco Magalhães Rios

Results The mean age was 8.73 years (min: 4, Max: 19), and 9 were females. The symptoms started before 1 year old in 93% of the sample and in 50% before 6 months. Urticaria was the most frequent manifestation in the 1st contact (60%), some progressing to anaphylaxis: the initial event in 40% of cases. Half of the patients responded to minimal amounts of LV, mainly (60%) in raw state. Symptoms a...

2016
Stephen McGovern Sonia Baconnais Pierre Roblin Pierre Nicolas Pascal Drevet Héloïse Simonson Olivier Piétrement Jean-Baptiste Charbonnier Eric Le Cam Philippe Noirot François Lecointe

Non-homologous end joining is a ligation process repairing DNA double strand breaks in eukaryotes and many prokaryotes. The ring structured eukaryotic Ku binds DNA ends and recruits other factors which can access DNA ends through the threading of Ku inward the DNA, making this protein a key ingredient for the scaffolding of the NHEJ machinery. However, this threading ability seems unevenly cons...

Journal: :International immunology 2001
D Frasca P Barattini G Tocchi L Guidi L Pierelli G Doria

The DNA-dependent protein kinase (DNA-PK) complex plays a crucial role in radiation-induced DNA damage recognition. The complex includes the ku heterodimer, which comprises ku 70 and ku 80 subunits, that binds DNA termini of breaks without sequence specificity, and the catalytic subunit DNA-PKCS: The activation of the DNA-PK complex was studied in X-irradiated peripheral blood mononuclear cells...

Journal: :RNA 2013
Andrew B Dalby Karen J Goodrich Jennifer S Pfingsten Thomas R Cech

Most nucleic acid-binding proteins selectively bind either DNA or RNA, but not both nucleic acids. The Saccharomyces cerevisiae Ku heterodimer is unusual in that it has two very different biologically relevant binding modes: (1) Ku is a sequence-nonspecific double-stranded DNA end-binding protein with prominent roles in nonhomologous end-joining and telomeric capping, and (2) Ku associates with...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1998
K Ghoshal Z Li S T Jacob

Metallothioneins (MT) are involved in the scavenging of the toxic heavy metals and protection of cells from reactive oxygen intermediates. To investigate the potential role of the protein Ku in the expression of MT, we measured the level of MT-I mRNA in the parental rat fibroblast cell line (Rat 1) and the cell lines that stably and constitutively overexpress the small subunit, the large subuni...

Journal: :Rheumatology 2008
C Schild-Poulter A Su A Shih O P Kelly M J Fritzler R Goldstein R J G Haché

OBJECTIVE To analyse the autoimmune response to DNA damage response factors in systemic autoimmune rheumatic disease (SARD) patients and to determine their association with autoantibodies to Ku antigen. METHODS We have screened the serum of 239 patients suffering from SARD, including systemic lupus erythematosus, systemic sclerosis and rheumatoid arthritis to detect the occurrence of autoanti...

Journal: :EMBO reports 2007
Jenny Paupert Stéphanie Dauvillier Bernard Salles Catherine Muller

Recent evidence shows that the DNA repair protein Ku is expressed on the surface of a subset of cells, where it contributes to adhesion and invasion processes, and also to viral or bacterial entry into target cells. Here, we show that Ku was expressed on the cell surface during activation of human monocytes and that its expression was independent of the conventional endoplasmic reticulum (ER)/G...

Journal: :The Keio journal of medicine 1986
S Nakamura

The antigenic heterogeneity of a long term cultured cell line has not been clearly demonstrated. In the present study, monoclonal antibodies (MoAbs) to an established cell line KU-2 derived from a human renal cell carcinoma were used to analyze antigenic variation of KU-2 and its subclones. Characterization of thus produced MoAbs was attempted by determining the binding ability to other establi...

2018
Taisuke Togari Yosuke Takaku Takashi Itagaki Naoko Katakura

1Department of Liberal Arts, The Open University of Japan, 2-11 Wakaba, Mihama-ku, Chiba 261-8586, Japan 2Japan Network of People Living with HIV/AIDS, 1-21-12-103, Hyakunincho, Shinjyuku-ku, Tokyo 169-0073, Japan 3Division of Health Administration, TIS Inc., 2-11-1, Nagatacho, Chiyoda-ku, Tokyo 100-6150, Japan 4School of Nursing, Nagoya City University, 1 Kawasumi, Mizuhocho, Mizuho-ku, Nagoya...

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