The Trf4p/Air2p/Mtr4p polyadenylation (TRAMP) complex recognizes aberrant RNAs in Saccharomyces cerevisiae and targets them for degradation. A TRAMP subcomplex consisting of a noncanonical poly(A) RNA polymerase in the Pol ss superfamily of nucleotidyl transferases, Trf4p, and a zinc knuckle protein, Air2p, mediates initial substrate recognition. Trf4p and related eukaryotic poly(A) and poly(U)...

A family with five members who have variable findings of leuconychia, knuckle pads, hearing loss, and palmoplantar hyperkeratosis is described. The findings in these subjects are compared with those noted in previously reported patients with Bart-Pumphrey syndrome. The range of disorders which include knuckle pads as part of the phenotype is reviewed.

Thorpe et al. (Reports, 1 June 2007, p. 1328) concluded that human bipedalism evolved from a type of bipedal posture they observed in extant orangutans with seemingly human-like extended knees. However, humans share knuckle-walking characters with African apes that are absent in orangutans. These are most parsimoniously explained by positing a knuckle-walking precursor to human bipedalism.

he extant medical literature lacks a discussion of the cultural tradition of bare-knuckle boxing among Irish Travelers, which is pertinent to traumatology given the possible medical complications of this practice. This cultural tradition is a risk factor for a potentially dangerous injury known as a “fight bite”. Irish Travelers are individuals belonging to nomadic families who originated in Ir...

The activity of the SR protein family of splicing factors in constitutive or alternative splicing requires direct interactions with the pre-mRNA substrate. Thus it is important to define the high affinity targets of the various SR species and to evaluate their ability to discriminate between defined RNA targets. We have analyzed the binding specificity of the 30-kDa SR protein 9G8, which contai...

Knuckle pads are well circumscribed thickenings of the skin over the metacarpophalangeal and, more commonly, the proximal interphalangeal joints. Although the association with several other clinical syndromes including Dupuytren's disease is well documented, most cases are idiopathic. We present a case of knuckle pads and briefly review the history and course of this disease.

Anatomical landmark of A1 pulley is important especially in minimal invasive surgery. The lengths and landmarks of A1 pulleys were evaluated in 510 preserved cadaver digits. The cadavers were 25 females and 26 males aged at the time of death ranged from 48 to 89 years. Measurements of A1 pulley lengths were made and used to predict the landmarks of the proximal pulley margins, which are related...

This paper proposes an enhanced method for personal authentication based on finger Knuckle Print using Gabor transform. In study shows that finger knuckle print (FKP) technique of a person can be used as a biometric trait in a biometric authentication system due to its uniqueness property. Hand-based person recognition provides a reliable, in low-cost and user-friendly viable solution for a ran...

The PTO driveline is the most common means of transferring power from a tractor to towed machinery and stationary equipment. While equipment manufacturers install shielding to protect operators and bystanders from coming in contact with operating PTO components (particularly around the knuckle), entanglement is still a cause of some of the most catastrophic agricultural work-related injuries. T...