In vivo disposition of Adriamycin (ADR) is characterized by rapid uptake into most tissues and long tissue transit time due to high affinity but slowly reversible binding to nuclear DNA (Harris & Gross, 1975; Terasaki et al., 1984). The role of drug metabolism in this scheme has not been fully elucidated (Chan et al., 1978). There is reason to believe that uptake of ADR into solid tumours behav...

Airport security checkpoints might take a lesson from the nuclear pore complex (NPC), where, according to Dange et al., there are no long lines and no slowdown despite the hubbub around them. The group used single-molecule video microscopy, with a localization precision of about the width of a protein, to track single molecules of labeled, cargo-carrying receptors entering the NPC in vivo. They...

Given a metabolic network in terms of its metabolites and reactions, our goal is to efficiently compute the minimal knock-out sets of reactions required to block a given behavior. We describe an algorithm that improves the computation of these knock-out sets when the elementary modes (minimal functional subsystems) of the network are given. We also describe an algorithm that computes both the k...