phytosis complex." 2,3 A bacterial and fungal culture may thus be necessary to identify all nail and foot pathogens. A clue that a patient has a significant bacterial infection is green discoloration of the nail, as in our patient. Unfortunately, because of the faster growth rate of bacteria, isolation of fungi is often not possible. The inability to isolate a fungus because of bacterial overgr...

The term telogen effluvium, first coined by Kligman in 1961, refers to the loss of club (telogen) hair in disease states of the follicle. Kligman's hypothesis was that whatever the cause of hair loss, the follicle tends to behave in a similar way, namely the premature termination of anagen. "The follicle is precipitated into catagen and transforms into a resting stage that mimics telogen." Ipso...

The assumption that the most effective way to use corticosteroids to suppress disease is to give these agents in divided doses two or three times daily was challenged by Reichling and Kligman (1961) and later by Harter, Reddy, and Thorn (1963). They suggested that alternate day administration could be equally satisfactory, with the advantage that less suppression of the hypothalamic-pituitaryad...

BACKGROUND Comedogenicity is an important consideration in the development of topical medications, cosmetics, and skin care products. The concept of "acne cosmetica" was developed to link the use of certain ingredients to comedo formation. Animal models were originally used to determine the comedogenic potential of raw materials with the assumption that finished formulations containing these in...

BACKGROUND There is no appropriate and reliable method of evaluating and monitoring severity in rosacea. OBJECTIVE To determine the importance of nailfold capillaroscopy as a diagnostic and prognostic method for patients with rosacea. METHODS A cross-sectional study where eight patients with rosacea and 8 control subjects were submitted to nailfold capillaroscopy from May to July 2009. We c...

The cutaneous manifestations of syphilis are many. Most commonly one sees macular, papular, and papulosquamous lesions. Rarely, except in infants, are the lesions vesicular and only occasionally are they pustular (Pillsbury, Shelley, and Kligman, 1956; Pariser, 1964). The pustular lesions may easily be misdiagnosed unless the clinician is aided by the presence of a persistent primary lesion or ...

Background: Comedogenicity is an important consideration in development of topical products, such as cosmetics. An animal test using rabbit ear has long been served as a model for prediction of comedogenicity of topical products, but correlation to the human skin remained controversial. Isopropyl myristate and cocoa butter which are used as positive controls in animal test, also used in human c...

Myoga is a fragrant plant which is the special product of Japan and is cultivated throughout Japan. According to our earlier investigation (unpublished data) of myoga cultivators in Japan, 8 of 35 cultivators experienced contact dermatitis in the harvest season. The purpose of this study was to assess the allergenicity of myoga and its major volatile components. The volatile components of myoga...

In herbivores such as the rabbit the regulation is easily overloaded; the addition of large amounts of cholesterol to the diet may result in a tenfold increase in the level of cholesterol in the serum. Even in omnivores such as poultry, dietary cholesterol causes a marked rise in serum cholesterol (March, Biely & Lindsay, 1964). Also in man, recent experiments have clearly shown that an excess ...