نتایج جستجو برای: kir gene

تعداد نتایج: 1142752  

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2009
Jeffrey M Venstrom Junting Zheng Nabila Noor Karen E Danis Alice W Yeh Irene Y Cheung Bo Dupont Richard J O'Reilly Nai-Kong V Cheung Katharine C Hsu

PURPOSE NK cells exhibit cytotoxicity against neuroblastoma. Gene polymorphisms governing NK cell function, therefore, may influence prognosis. Two highly polymorphic genetic loci instrumental in determining NK cell responses encode the NK cell killer immunoglobulin-like receptors (KIR) and their class I human leukocyte antigen (HLA) ligands. We hypothesized that patients with a "missing ligand...

2013
Florian Babor Johannes C. Fischer Markus Uhrberg

The antileukemic potential of natural killer (NK) cells has been of rising interest in recent years. Interactions between inhibitory killer cell immunoglobulin-like receptors (KIR) and HLA class I ligands seem to be critically involved in the immunosurveillance process. It is also well established that mismatching of HLA class I-encoded KIR ligands in the setting of hematopoietic stem cell tran...

2013
Jan Futas Petr Horin

Natural killer (NK) cells have important functions in immunity. NK recognition in mammals can be mediated through killer cell immunoglobulin-like receptors (KIR) and/or killer cell lectin-like Ly49 receptors. Genes encoding highly variable NK cell receptors (NKR) represent rapidly evolving genomic regions. No single conservative model of NKR genes was observed in mammals. Single-copy low polymo...

2013
Sanne Vendelbosch Martin de Boer Remko A. T. W. Gouw Cynthia K. Y. Ho Judy Geissler Wendy T. N. Swelsen Michael J. Moorhouse Neubury M. Lardy Dirk Roos Timo K. van den Berg Taco W. Kuijpers

Killer immunoglobulin-like receptors (KIRs) are involved in the regulation of natural killer cell cytotoxicity. Within the human genome seventeen KIR genes are present, which all contain a large number of allelic variants. The high level of homology among KIR genes has hampered KIR genotyping in larger cohorts, and determination of gene copy number variation (CNV) has been difficult. We have de...

Journal: :Endocrine 2014
Elham Ashouri Mohammad Hossein Dabbaghmanesh Gholamhossein Ranjbar Omrani

Killer cell immunoglobulin-like receptors (KIR) regulate the effector function of natural killer (NK) cells and the subset of T cells with memory phenotype. The number and type of genes that encode KIR receptors substantially varied between individuals and between populations. Specific KIR receptors are known to be associated with certain diseases. The present study was undertaken to investigat...

2010
Chul-Woo Pyo Lisbeth A. Guethlein Quyen Vu Ruihan Wang Laurent Abi-Rached Paul J. Norman Steven G. E. Marsh Jeffrey S. Miller Peter Parham Daniel E. Geraghty

The fast evolving human KIR gene family encodes variable lymphocyte receptors specific for polymorphic HLA class I determinants. Nucleotide sequences for 24 representative human KIR haplotypes were determined. With three previously defined haplotypes, this gave a set of 12 group A and 15 group B haplotypes for assessment of KIR variation. The seven gene-content haplotypes are all combinations o...

Journal: :Blood 2010
Sarah Cooley Daniel J Weisdorf Lisbeth A Guethlein John P Klein Tao Wang Chap T Le Steven G E Marsh Daniel Geraghty Stephen Spellman Michael D Haagenson Martha Ladner Elizabeth Trachtenberg Peter Parham Jeffrey S Miller

Killer-cell immunoglobulin-like receptor (KIR) genes form a diverse, immunogenetic system. Group A and B KIR haplotypes have distinctive centromeric (Cen) and telomeric (Tel) gene-content motifs. Aiming to develop a donor selection strategy to improve transplant outcome, we compared the contribution of these motifs to the clinical benefit conferred by B haplotype donors. We KIR genotyped donors...

Journal: :Journal of immunology 2005
Hans-Ingo Trompeter Natalia Gómez-Lozano Simeon Santourlidis Britta Eisermann Peter Wernet Carlos Vilches Markus Uhrberg

The generation of killer cell Ig-like receptor (KIR) expression patterns in NK cells involves variegated silencing of KIR genes by DNA methylation. To identify regulatory elements involved in KIR gene activation, upstream regions of KIR genes were functionally characterized in NK3.3 cells as well as in primary NK cells. Three kinds of KIR promoters were defined, controlling clonally expressed K...

2016
Giorgio La Nasa Marianna Greco Roberto Littera Sara Oppi Ivana Celeghini Rossella Caria Sara Lai Rita Porcella Massimo Martino Alessandra Romano Francesco Di Raimondo Andrea Gallamini Carlo Carcassi Giovanni Caocci

BACKGROUND Interim positron emission tomography after 2 cycles of ABVD (iPET-2) is a good predictor of outcome in advanced-stage classic Hodgkin lymphoma. So far, there are no other prognostic biomarkers capable of identifying chemotherapy refractory patients with comparable accuracy. Despite the considerable amount of evidence suggesting that antitumor immune surveillance is downregulated in c...

2010
James A. Traherne Maureen Martin Rosemary Ward Maki Ohashi Fawnda Pellett Dafna Gladman Derek Middleton Mary Carrington John Trowsdale

The fine-scale structure of the majority of copy number variation (CNV) regions remains unknown. The killer immunoglobulin receptor (KIR) gene complex exhibits significant CNV. The evolutionary plasticity of the KIRs and their broad biomedical relevance makes it important to understand how these immune receptors evolve. In this paper, we describe haplotype re-arrangement creating novel loci at ...

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