Background: Over-expression of CD117 and cytokeratin 20 (CK20) is seen in many malignancies. Given that few studies have been conducted regarding the role of these biomarkers in the etiology of bladder tumours, this study aimed to evaluate the prognostic value of CD117 and CK 20 biomarkers in the benign and malignant tumours of urinary bladder carcinoma. Methods: This case-control study was co...

Primary renal plasmacytomas are an extremely rare clinical condition. Their management is particularly challenging due to the paucity of evidence, with only just over a dozen previously reported cases. We report a case of a primary extramedullary plasmacytoma of the kidney and performed a review of the literature. The case is presented as a learning point that it is imperative to keep plasmacyt...

4 Glycosaminoglycans were inyestigated in surgically removed human liver and kidney tumours by applying biochemical methods. Four liver adenoma, 6 focal nodular hyperplasia and 9 primary hepatocellular carcinoma samples were compared with nermal liyer frorn autopsy cases and also with liyer tissue adjacent to PHC. The studies on kidney included 14 renal cell carcinoma and 4 wilms' tumour sample...

-The growth and metastatic spread of human tumours in immuno suppressed hamsters is described. A variety of human tumours were transplanted to the flank or the cheek pouch of the hamsters. Immunosuppression was obtained by combined thymectomy and ATS treatment. In the period up to 4 months after implantation, metastases to the lungs were observed with carcinomata of breast, colon, larynx and ki...

AIMS The Wilms' tumour gene (WT1) product is expressed during the development of the urogenital system. This study was undertaken to evaluate four anti-WT1 antibodies and use the most specific one to examine the expression of WT1 in formalin fixed, paraffin wax embedded tissues from human embryos, fetuses, and paediatric renal neoplasms. METHODS The antibodies were assessed on paraffin sectio...

Other tumours that have been reported in HIV -positive persons but for which an association with the infection is not convincing incIude mesothelioma (Behling et al., 1993), cerebral glial tumours (Chamberlain, 1994; MouIignier et al., 1994) and cancer of the colon (Kaplan et al., 1987; Cappell et al., 1988), pancreas (Kaplan et al., 1987; Monfardini et al., 1989) and kidney (Monfardini et al.,...

Although practically every form of tumour found in the-,adult kidney has been reported in childhood, the overwhelming majority of primary renal tumours in childhood are embryomata (syn: Wilms' tumour). Benign renal tumours are rare in children. Adenomata seldom cause symptoms and are generally discovered at autopsy. Fibromata are usually small and sub-capsular but may grow slowly over a period ...