background few studies have focused on patients’ characteristics that affects acute kidney injury (aki) after total knee replacement surgery (tkr). objectives the primary objective of this retrospective study was to identify patients’ characteristics associated with aki after tkr. patients and methods between january 2008 and december 2009, 659 patients with a mean age of 67.1 years (range, 39-...

objective(s): this study aims to determine the effects of ozone therapy on restoring impaired nrf2 activation to ameliorate chronic tubulointerstitial injury in rats with adenine-induced ckd. materials and methods: sprague–dawley rats were fed with 0.75% adenine-containing diet to induce ckd and chronic tubulointerstitial injury. ozone therapy was administered by rectal insufflation. after 4 we...

our study evaluated the differences between early and late hemodialysis (hd) initiation in the intensive care unit (icu) according to the rifle (risk, injury, failure, loss, and end-stage renal failure) and akin (acute kidney injury network) classifications. on the assumption that early initiation of hd in critical patients according to the rifle and akin criteria decreases mortality, we retros...

conclusions a few eligible articles on seismo-nephrology were found in iran, and a limited number of current articles had poor or fair quality. as expected, the chaotic situation after mass disasters and the lack of documentation led to the loss of much important data on the diagnosis and management of victims. lessons learned from the current researches can be used as a valuable guide for futu...

Introduction: Renal ischemia/reperfusion (I/R) injury due to reactive oxygen species (ROS) formation is the main cause of acute kidney damage. Nitric oxide (NO) biosynthesis and oxidative stress are closely related to the pathogenesis of renal I/R injury. This study was undertaken to determine the effects of L-arginine (L-arg) as NO donor and aerobic exercise (EX) and also the combination of L-...

objective(s):recently cell therapy is a promising therapeutic modality for many types of disease including acute kidney injury (aki). due to the unique biological properties, mesenchymal stem cells (mscs) are attractive cells in this regard. this study aims to transplant mscs equipped with nuclear factor e2-related factor 2 (nrf2) in rat experimental models of acute kidney and evaluate regenera...

Objective(s): This study aims to determine the effects of ozone therapy on restoring impaired Nrf2 activation to ameliorate chronic tubulointerstitial injury in rats with adenine-induced CKD. Materials and Methods: Sprague–Dawley rats were fed with 0.75% adenine-containing diet to induce CKD and chronic tubulointerstitial injury. Ozone therapy was administered by rectal insufflation. After 4 we...

objective(s): renal ischemia reperfusion (ir) contributes to the development of acute renal failure (arf). oxygen free radicals are considered to be principal components involved in the pathophysiological tissue alterations observed during renal ir. the purpose of this study was to investigate the effect of co-administration of melatonin (mel) and erythropoietin (epo), potent antioxidant and an...

background: renal ischemia reperfusion (ir), one of the most important causative mechanisms of acute kidney injury, is a major clinical problem that occurs in some hospitalized patients. the aim of this study was to investigate the effects of hydroxytyrosol (ht) on renal ischemia-reperfusion injury in mice. methods: male mice were randomly assigned to three groups (n = 9): (1) sham operated, (2...

conclusions in our study, hydroalcoholic extract of cyperus scariosus linn. offered nephroprotection in the form of aki prevention and for the treatment of established aki. results serum creatinine was significantly increased (p < 0.05) while 24 hours urine output, urine creatinine, and serum protein were significantly decreased (p < 0.05) in rats treated with gentamicin as compared to the cont...