Kidney function has been traditionally identified with glomerular filtration rate (GFR). However, the kidney has multiple functions beyond filtration and a careful evaluation of its whole spectrum of activities should be carried out. Furthermore, the kidney presents a functional reserve capacity both at glomerular and tubular level. In presence of appropriate stimuli, patients with intact nephr...

Introduction: CKD is a clinical syndrome which occurs due to irreversible loss of renal function leading metabolic, endocrine, excretory and synthetic resulting in accumulation non – protein nitrogenous substances leads metabolic derangements ends up with distinct manifestations. Aim: To study thyroid abnormalities patients chronic kidney disease. correlate the severity failure. differentiate p...

Aim: The aim of this study was to compare the diagnostic value of serum creatinine and cystatin c in detection of minor changes at early stages of development of diabetic kidney disease. Background: Loss of kidney function is grossly under diagnosed due to the inherent weakness in the traditional kidney function markers, and cumbersome and uneconomical nature of the gold standard. The imperativ...

backgrounds: g6pd deficiency is the most common enzymopathy of red blood cells. the clinical symptoms of favism are jaundice, hematuria and haemolytic anaemia that seem to affect liver and kidney in long term. thus we evaluate kidney and liver function of favism patients in an endemic area of the disease with a high rate of fava beans cultivation. methods: this study was performed on favism pat...

gabapentin (gpn) is a new antiepileptic agent currently in used as add-on therapy in adult patients suffering from partial seizures. the extent of liver damage at different dosage and long term treatment with gpn is not yet clear. therefore this study was undertaken to find out the possibility of liver damage by this drug. adult male (wistar) rats of 180-220 g were administered intraperitoneall...

Objective(s): Kidney disease is a global health problem that needs a solution to its therapy. In the previous study, we found that protein hydrolysate of green peas origin of Indonesia hydrolysed by bromelain (PHGPB) showed improve kidney function in cisplatin-induced nephropathy rats. In this study, we investigated the effect of PHGPB to obtain effective dose that exe...

BACKGROUND Acute kidney injury is frequently observed at the intensive care unit, after surgery, and after toxic drug administration. A rise in serum creatinine and a fall in urine output are consequences of much earlier injury to the most sensitive part of tubular cells located at the proximal tubule. The aim of the present study was to investigate the course of two cell-cycle arrest urinary b...