Kidney damage is defined as structural or functional abnormalities of the kidney with or without decreased glomerular filtration rate (GFR), manifest by either pathological abnormalities or abnormalities in blood or urine tests or imaging studies 1,2 . The term chronic kidney disease (CKD) refers to patients with kidney damage or a GFR less than 60ml/min/1.73m 2 with or without kidney damage fo...

Hequn Zou1, Yuxin Wang2, Guimian Zou3 and Jianxin Wan4 1Institute of Nephrology and Urology, The 3rd Affiliated Hospital of Southern Medical University, Guangzhou, 2Department of Nephrology, The No. 2 Hospital of Xiamen, Fu Jian Medical University, Xiamen, 3Nephrology Department of Guilin 181 Hospital & Guangxi Provincial Key Laboratory of Metabolic Disease Research, Guilin, 4Department of Neph...

production in rat mesangial cells (MC) by high glucose con-Goldschmeding R. CTGF: expression in the rat Thy 1.1 model centrations, mechanical strain and TGF-b: role in diabetic and regulation in mesangial cells and podocytes. J Am Soc glomerulosclerosis. Calcium oxalate monohydrate crystals stimulate gene expression TJ, Weening JJ, Goldschmeding R. CTGF in hypertensive in renal epithelial cells...

Novel biomarkers are required to improve the timely detection of early acute kidney injury (AKI) and to improve the differential diagnosis, prognostic assessment, and management of AKI cases. It is anticipated that novel biomarkers of early structural AKI ('acute kidney damage') will provide critical diagnostic and prognostic stratification and complement functional markers such as serum creati...

Objective(s): Precision-cut tissue slices are considered an organotypic 3D model widely used in biomedical research. The comet assay is an important screening test for early genotoxicity risk assessment that is mainly applied on in vitro models.  The aim of the present study was to provide a 3D organ system for determination of genotoxicity using a modified method of the comet assay since the s...

It has been estimated that about 20% of men and 25% of women between the ages of 65 and 74 have some degrees of chronic kidney. This complication is attributed to oxidative stress. Oxidative stress is an important factor contributing to kidney damage by increasing production of oxidants, particularly insufficiency of endogenous antioxidant defense system. Medicinal plants antioxidants are able ...

Background and Aims: Formaldehyde, a colorless aldehyde with pungent odor, has negative effects on systems of the body. Considering, there are a little data about protective substances against kidney damage induced by formaldehyde, the aim of the present study was to examine the effects of different doses of N-acetyl cysteine on biochemical and histopathological parameters in k...

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