A major obstacle to the development of effective treatment of Alzheimer's disease (AD) is successfully delivery of drugs to the brain. We have previously identified a series of benzothiazole phosphonate compounds that block the interaction of amyloid-β peptide with amyloid-β binding alcohol dehydrogenase (ABAD). A selective and sensitive method for the presence of three new benzothiazole ABAD i...

Current strategies for the treatment of Alzheimer's disease (AD) involve tackling the formation or clearance of the amyloid-beta peptide (Aβ) and/or hyper-phosphorylated tau, or the support and stabilization of the remaining neuronal networks. However, as we gain a clearer idea of the large number of molecular mechanisms at work in this disease, it is becoming clearer that the treatment of AD s...

the doruneh fault is one of the longest and most prominent faults in iran. however, only two recorded historical earthquakes with magnitudes more than 7 might be related to this fault. for getting more information on this fault more investigation in different fields are required. fault displacement is one of the most important parameters needed to explore the fault activity. in this study, with...

In a Perspective accompanying Abad-Franch and colleagues, Lorenz von Seidlein, Alexander Kekulé, and Daniel Strickman discuss the importance of developing effective strategies to minimize mosquito-borne transmission of human diseases.

according to historical sources, in time of oljaito reign the city was built at the foot hills of bisotun mountain that called sultan abad-e chamchamal. it was a main political region during the ilkhanid period.due to the lack of archaeological studies, the exact position of this important site remains unclear and its exact location is the problems questioned in the archaeology of that region.i...

BACKGROUND Since Pars Abad district had been known as a focus of visceral leishmaniasis (VL) in Ardabil Province but the prevalence of the disease in nomadic tribes has not been determined, thus, this study was conducted. METHODS This descriptive cross-sectional study was conducted on children up to 12yr old of nomadic tribes from Pars Abad County, Ardabil Province, Iran in 2015. For each ind...

In the acute setting, the majority of patients affected by uncomplicated acute type B aortic dissection (ABAD) can be managed with medical therapy. In these patients, inhospital outcome is generally acceptable, with mortality rates of 1-10% (1,2). However, long-term outcomes in this group is less positive, with a mortality rates reported as 2025% within 3 years. Predictors of long-term complica...

We show that there may be a Milliken-Taylor ultrafilter with infinitely many near coherence classes of ultrafilters in its projection to ω, answering a question by López-Abad. We show that k-coloured Milliken-Taylor ultrafilters have at least k + 1 near coherence classes of ultrafilters in its projection to ω. We show that the Mathias forcing with a Milliken-Taylor ultrafilter destroys all Mill...

Alzheimer׳s disease (AD) is one of the most common dementias showing slow progressive cognitive decline. Progression of intracerebral accumulation of beta amyloid (Aβ) peptides by the action of amyloid binding alcohol dehydrogenase (ABAD), a mitochondrial enzyme and β-site amyloid precursor protein cleaving enzyme 1 (BACE1) and the degradation of Acetylcholinesterase (AChE) the main pathologica...

Neurotoxicity of beta-amyloid peptide (A beta) in Alzheimer's disease (AD) is usually thought to arise from the nonspecific effects of high concentrations of A beta on vulnerable neurons, resulting in membrane destabilization and increasing intracellular calcium concentration. This review advances the hypothesis that at early stages of AD, when A beta is present in lower amounts, its ability to...