background cancer stem cells play crucial roles in resistance to therapeutic schemes and relapse of disease, so it is important to find targeted therapies that kill them selectively. breast cancer is the most common cancer in females living in all part of the world including iran and it has an important burden in public health with direct impact on patients’ families. breast cancer in young adu...

background: mesenchymal stem cells (mscs) are important candidates for msc-based cellular therapy. current paradigm states that mscs support local progenitor cells in damaged tissue through paracrine signaling. therefore, study of paracrine effects and secretome of mscs could lead to the appreciation of mechanisms and molecules associated with the therapeutic effects of these cells. this study ...

objective(s):mesenchymal stem cells (mscs) derived from wharton’s jelly (wj-mscs) are now much more appealing for cell-based infertility therapy. hence, wj-mscs differentiation toward germ layer cells for cell therapy purposes is currently under intensive study. materials and methods: mscs were isolated from human wharton’s jelly and treated with bmp4, retinoic acid (ra) or co-cultured on human...

Stem/progenitor cell based therapeutic approach in our daily routine clinical practice, has been elusive dream in medical sciences and improvement of stem cell homing as one of major challenges in cell therapy programs, has been considered a promising milestone. It has been proved that stem/progenitor cells exhibit a homing response to injured tissues/organs, mediated by interactions of chemoki...

ever-increasing advances in the field of bioethics have been encouraged by recent developments of biomedical technolo-gies. stem cell research and therapy are among the most promising approaches in medicine of which are raised some ethical chal¬lenges. likewise, the therapeutic potential of stem cell-based therapies created new policy concerns for health care sys¬tems, particularly the issue of...

cell therapy is a modern approach in the treatment of most of the diseases which uses stem cells and it has been recently developed rapidly. cell therapy has shown satisfactory results in this way. our country, iran, has played an important role in the development of this new method and the results of stem cell treatment used for the most of the diseases were successful. the results have led to...

Introduction: Mechanical stimulation of human mesenchymal stem cells has demonstrated changes in many cell behaviours such as adhesion, migration, growth and differentiation through mechanotransductive pathways. These include experiments on effect of nanotopography 1, shear stress, stiffness of extracellular matrix 2, strain, stress and acoustic wave energy 3 on cells. In this research we wer...

epilepsy is one of the most common neuroinflammatory disorders that affect more than 50 million people worldwide. excessive electrical discharges in neurons following neural cell damage or loss leads to recurrent seizures, which are described as epilepsy. one of the most common and difficult to treat types of epilepsy is temporal lobe epilepsy (tle), which results from hippocampal sclerosis. cu...

Cell therapy is a modern approach in the treatment of most of the diseases which uses stem cells and it has been recently developed rapidly. Cell therapy has shown satisfactory results in this way. Our country, Iran, has played an important role in the development of this new method and the results of stem cell treatment used for the most of the diseases were successful. The results have led to...

This paper investigates a possible practical solution for reasonable oxygen supply during the pluripotent stem cells expansion processes, where the stem cells propagate as aggregates in stirred-suspension bioreactors. Low glucose and low oxygen concentrations are preferred for efficient proliferation of pluripotent stem cells. However, strong oxygen limitation, especially inside of cell aggrega...