نتایج جستجو برای: ketoacyl
تعداد نتایج: 610 فیلتر نتایج به سال:
Phenotypic screens for bactericidal compounds are starting to yield promising hits against tuberculosis. In this regard, whole-genome sequencing of spontaneous resistant mutants generated against an indazole sulfonamide (GSK3011724A) identifies several specific single-nucleotide polymorphisms in the essential Mycobacterium tuberculosis β-ketoacyl synthase (kas) A gene. Here, this genomic-based ...
10.1128/AEM.67.1.426-433.2001. 2001, 67(1):426. DOI: Appl. Environ. Microbiol. Yoshikatsu Murooka Hisayo Ono, Mitsuo Yamashita, Yoshinobu Kaneko and Pornpimon Kiatpapan, Hajime Kobayashi, Maki Sakaguchi, Biosynthesis ), Which Are Essential for Fatty Acid accBCDA Acetyl Coenzyme A Carboxylase ( ) and fabH Carrier Protein Synthase III ( -Ketoacyl-Acyl β Genes for plantarum Lactobacillus Molecular...
The Streptomyces coelicolor fab (fatty acid biosynthesis) gene cluster (fabD-fabH-acpP-fabF) is cotranscribed to produce a leaderless mRNA transcript. One of these genes, fabH, encodes a ketoacyl synthase III that is essential to and is proposed to be responsible for initiation of fatty acid biosynthesis in S. coelicolor.
We use mass spectrometry analysis and molecular modelling to show the established antimicrobial inhibitor 4,5-dichloro-1,2-dithiol-3-one (HR45) acts by forming a covalent adduct with the target β-ketoacyl-ACP synthase III (FabH). The 5-chloro substituent directs attack of the essential active site thiol (C112) via a Michael-type addition elimination reaction mechanism.
A DNA fragment containing the Pseudomonas aeruginosa fabD (encoding malonyl-coenzyme A [CoA]:acyl carrier protein [ACP] transacylase), fabG (encoding beta-ketoacyl-ACP reductase), acpP (encoding ACP), and fabF (encoding beta-ketoacyl-ACP synthase II) genes was cloned and sequenced. This fab gene cluster is delimited by the plsX (encoding a poorly understood enzyme of phospholipid metabolism) an...
Salts activate the fatty acid-synthesizing system of Escherichia coli and several of its component enzymes. The 3hydroxyacyl coenzyme A dehydrogenase from pig heart, one of the enzymes of fatty acid oxidation, is also stimulated by salts. Although all cations examined produce this stimulation, the activation patterns caused by monovalent cations are clearly distinct from those of divalent catio...
The emergence of strains of Plasmodium falciparum resistant to the commonly used antimalarials warrants the development of new antimalarial agents. The discovery of type II fatty acid synthase (FAS) in Plasmodium distinct from the FAS in its human host (type I FAS) opened up new avenues for the development of novel antimalarials. The process of fatty acid synthesis takes place by iterative elon...
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