Procedures involving complex surgical techniques in rats, such as placement of abdominal aortic graft require extended duration of surgical anesthesia, which often can be achieved by repeated administrations of xylazine-ketamine combination. However such repeated anesthetic administration, in addition to being technically challenging, may be associated with potential adverse events due to cumul...

OBJECTIVE To evaluate the effect of the mode of mechanical ventilation (MV) on the dose of intravenous anesthetic during 3 hours of ketamine/xylazine anesthesia. STUDY DESIGN Prospective laboratory study. ANIMALS Sixty-one adult male New Zealand White rabbits. METHODS Rabbits were anesthetized (ketamine/xylazine 35 + 5 mg kg(-1), IM), the trachea was intubated and randomized to four group...

A robust CE method for the simultaneous determination of the enantiomers of ketamine and norketamine in equine plasma is described. It is based upon liquid-liquid extraction of ketamine and norketamine at alkaline pH from 1 mL plasma followed by analysis of the reconstituted extract by CE in the presence of a pH 2.5 Tris-phosphate buffer containing 10 mg/mL highly sulfated beta-CD as chiral sel...

Objective: It was aimed to investigate the effects of ketamine combination administered with xylazine used for general anesthesia in dogs on arterial blood pressure, heart rate, and body temperature.Materials Methods: In study, a total 20 dogs, 14 females 6 males, from various breeds ages 1 5, which undergone elective ovariohysterectomy or castration according weights. mg/kg (xylazine hydrochlo...

UNLABELLED The purpose of this study was to evaluate the feasibility of absolute quantification of regional cerebral glucose utilization (rCMR(glc)) in mice by use of (18)F-FDG and a small animal PET scanner. rCMR(glc) determined with (18)F-FDG PET was compared with values determined simultaneously by the autoradiographic 2-(14)C-DG method. In addition, we compared the rCMR(glc) values under is...

Anesthesia for mice is commonly performed through the injection of parenteral agents via the intraperitoneal (IP) route. Variability in anesthetic sensitivities has been noted in mice resulting in inconsistencies in anesthetic depth and/or mortality. Anesthetic protocols that improve consistency and safety are needed. The objectives of this study were to assess the effects of intraperitoneal (I...

the objective of this study was to evaluate several drug combinations for intraperitoneal anaesthesia in laboratory rats. following dose determination of anaesthetics in a pilot study, 45 healthy adult male rats were randomly assigned in 9 treatment groups and received propofol (alone or in combination with xylazine, midazolam, or ketamine) or ketamine (in combination with xylazine, midazolam, ...

Objective- This study aimed to compare sedation efficacy in intranasal administration of xylazine, diazepam and midazolam with or without ketamine in Chough. Design- To determine the sedation efficacy, an experimental in vivo study was employed. Animals- Seven healthy Choughs were examined in the current study. Procedu...

Purpose: To compare, by continuous infusion of ketamine or medetomidine combined to methotrimeprazine and buprenorphine, ketamine and midazolam, the degree of hypnosis, myorelaxation, anesthetic quality and surgical feasibility through evaluation of possible parametric alterations and recovery quality. Methods: 20 healthy adult females dogs, aged 3 to 5 years, body weight between 7 and 15 kg, w...

ABSTRACT Introduction: Oral mucositis (OM) is considered the most frequent acute side effect of antineoplasic treatment, with ulcerative lesions resulting from a painful symptomatology, affecting oral cavity in response to Antineoplastic treatment. In order study these effects, experiments animal models are necessary, using antineoplastic drugs for induction OM and anesthetics, mainly Ketamine ...