bilirubin induced brain damage is still a common cause of morbidity and mortality in nigerian infants. no much success has been recorded in decades despite the fact that brain damage from bilirubin toxicity in the newborn is easily preventable with affordable and effective means. we report a case of a newborn with acute bilirubin encephalopathy. this case was considered of interest because the ...

BACKGROUND Exchange transfusion (ET) for severe neonatal hyperbilirubinemia (SNH) is frequently undertaken in low- and middle-income countries (LMIC), in sharp contrast to the prevailing practice in high-income countries. However, the criteria for initiating this procedure in settings with limited resources for treating infants with SNH have not been systematically explored. OBJECTIVE To iden...

At one time kernicterus was most commonly associated with haemolytic disease of the newborn. With the introduction of adequate exchange transfusions this complication, whether due to Rh or to ABO incompatibility, has been virtually eliminated. In 1950 two groups of workers, Aidin, Corner and Tovey in this country and Zuelzer and Mudgett in America, independently drew attention to the fact that ...

Bilirubin-induced neurologic dysfunction (BIND) and kernicterus has been used to describe moderate to severe neurologic dysfunction observed in children exposed to excessive levels of total serum bilirubin (TSB) during the neonatal period. Here we use a new mouse model that targets deletion of the Ugt1 locus and the Ugt1a1 gene in liver to promote hyperbilirubinemiainduced seizures and central ...

Jaundice (also known as hyperbilirubinemia) is a yellowish-greenish pigmentation of the sclera and skin caused by an increase in bilirubin production or a defect in bilirubin elimination. Management of hyperbilirubinemia is one of the most common reasons for readmission of a newborn. Prolonged unconjugated hyperbilirubinemia can result in acute bilirubin encephalopathy and eventually develop in...