A balance of histone acetylation and deacetylation governs the regulation of genes that are involved in the differentiation and stratification of the mammalian epidermis. Class II HDACs (HDAC4, 5, 6, 7, 9, 10) frequently undergo nucleocytoplasmic flux resulting in gene derepression. Of the Class I HDACs (HDAC1, 2, 3, 8), HDAC2 has only been described in a nuclear setting. Here we report that a ...

Malignant mesothelioma is an uncommon neoplasm arising in body cavities lined by the mesothelium. Immunohistochemical stains are useful for making a diagnosis, but the correct combination of antibodies as should be selected in a comprehensive assessment. A peritoneal origin combined with desmoplastic histology is an extremely rare disease entity. Here, we report a case of the primary peritoneal...

Keratin is an intermediate filamentous protein generally found in the surface epithelium (Clausen et al., 1986; Steinert et al., 1995; Coulombe et al., 1990; Neville et al., 2002). Their role is to protect the underlying structures, which is one of the prime functions of surface epithelium (Tencate, 1998). The keratin synthesis reflects the differentiation level of normal epithelial cell as wel...

The keratin polypeptide pattern of newborn mouse back, ear, and tail epidermis is uniform and consists of eight individual proteins with a molecular weight range of 46,000 to 67,000. In the adult animal, the keratin patterns of the corresponding body sites are both different from the neonatal pattern and different among themselves. Most notably, ear and tail epider mis contains a high-molecular...

Epithelial functions are fundamentally determined by cytoskeletal keratin network organization. However, our understanding of keratin network plasticity is only based on analyses of cultured cells overexpressing fluorescently tagged keratins. In order to learn how keratin network organization is affected by various signals in functional epithelial tissues in vivo, we generated a knock-in mouse ...

Keratin filaments form cytoskeletal networks in epithelial cells. Dynamic rearrangement of keratin filament networks is required for epithelial cells to perform cellular processes such as cell migration and polarization; however, the mechanism governing keratin filament rearrangement remains unclear. Here, we describe a novel mechanism of keratin cytoskeleton organization mediated by casein kin...

background; feather waste is generated in large amounts as a by-product of commercial poultry processing. the main component of feather is keratin. the main purpose of this study was to identify bacillus spp. (the keratinolytic bacteria) that are able to degrade the feather for producing keratin. methods; bacillus spp. were isolated from the waste of poultries located in miyaneh city. the bacte...

In our research, we explored the relationship between Keratin 26 and the regulation of fine hair, BMP signaling pathway, MT, FGF5, and IGF-I. The result of hybridization in situ revealed that Keratin 26 was specially expressed in cortex of skin hair follicles; the result of immunohistochemistry indicated that Keratin 26 was expressed in internal root sheath, external root sheath. Then, Real-tim...

Using murine monoclonal antibodies TE-4 and TE-7 raised against human thymic stroma, we identified two distinct and mutually exclusive thymic microenvironment components: the thymic endocrine epithelium (TE-4+) and mesodermal-derived fibrous stroma (TE-7+). TE-4-reactive epithelium did not react with antibody TE-7, contained thymosin alpha 1 and keratin, and expressed other known markers of thy...

Hair-derived keratin biomaterials composed mostly of reduced keratin proteins (kerateines) have demonstrated their utility as carriers of biologics and drugs for tissue engineering. Electrostatic forces between negatively-charged keratins and biologic macromolecules allow for effective drug retention; attraction to positively-charged growth factors like bone morphogenetic protein 2 (BMP-2) has ...