INTRODUCTION  Keloids are benign tumors arising from abnormal healing of the skin, and there are several procedures available for their treatment. OBJECTIVE  The objective of this study was to evaluate the outcomes of patients undergoing treatment of keloids after ear, nose, and throat (ENT) surgeries at our service center. METHOD  We conducted thorough, retrospective and prospective analys...

OBJECTIVE Little is known about telomere dynamics in keloids. As keloid formation is dependent on cell replication, in theory telomeres should be shorter in keloids than in normal skin. We examined this concept in the present study. METHODS We measured by Southern blot analysis telomere length in keloids and in adjacent normal skin of 16 individuals. When available, we also measured telomere ...

Keloids are caused by excessive scar formation that leads to scar growth beyond the initial scar boundaries. Keloid formation and progression is promoted by mechanical stress such as skin stretch force. Consequently, keloids rarely occur in paralyzed areas and areas with little skin tension, such as the periauricular region. Therefore, periauricular incision is commonly performed for face lifts...

Health care providers have long struggled with recurrent and hard Importance to treat keloids. Advancing our understanding of natural history and risk factors for development of large, very large and massive neck keloids can lead to improved treatment outcomes. Clinical staging system for the categorization of keloid lesions, as well as grouping of keloid patients according to the extent of ski...

Keloids are the result of an aberrant wound healing response that leads to scar tissue expanding above and beyond boundaries original cutaneous injury. An estimated 2-4% population has keloids, with persons color having increased predisposition. Besides being cosmetically disfiguring, keloids can be both painful pruritic, significantly affecting patients’ quality life (QoL). Our aim was assess ...

background: keloids are benign fibrous dermal tumors originating from skin injury after surgery, piercing or others wounds. materials and methods: sixty-two patients with keloids were treated postoperatively using orthovoltage irradiation. the total dose delivered was 12 gy in three consecutive days, 4gy per fraction. treatment started 24 h after surgery. the median follow-up was 44.5 months. r...

keloids are aesthetically disfiguring and severely disabling. the optimal treatment remains undefined. this clinical study, evaluate the efficacy and side effects of combined topical silicone and 5-fluorouracil on the prevention of keloids. in this double blind randomized clinical trial, fifty patients with keloids were randomly allocated in two groups. the control group were treated by periles...

The present study aimed to investigate the genetic effects of hydrocortisone (HC) treatment on keloids and screen medicines to be used in a combination therapy of keloids with HC. The dataset GSE7890 was downloaded from Gene Expression Omnibus. It contained data regarding 4 fibroblast samples from normal scar tissue and 5 samples from keloid tissue with HC treatment, as well as 5 samples from n...

BACKGROUND Keloids and hypertrophic scars represent excessive scarring. They require different therapeutic approaches, which can be hampered because of an apparent lack of morphologic difference between the two diseases. OBJECTIVE This study investigated the clinical and dermoscopic features of keloids and hypertrophic scars in order to help dermatologists distinguish these lesions better. ...

Keloid disorder (KD) is an inherited wound healing ailment, frequently seen among Africans /African Americans and Asians.  Genetics of this disorder continues to be obscure and poorly understood.  Clinical manifestation of KD is quite variable and very diverse, spanning from individuals with one or very few small keloidal lesions, to those with numerous and very large lesions covering large por...