نتایج جستجو برای: k742 human chronic myeloid leukemia cells
تعداد نتایج: 3106524 فیلتر نتایج به سال:
follicular dendritic cells or dendritic reticulum cells are important components of the immune system essential for antigen presentation. malignancies arising from these cells are uncommon and the first case was reported in 1986. the most common sites of follicular dendritic cell sarcomas are lymph nodes, especially cervical, axillary and mediastinal regions, but extranodal sites including head...
Objective: Lymphoid enhancer-binding factor-1 (LEF1) is one of the key regulators lymphocyte proliferation and its aberrant expression a prognostic factor for lymphoid or myeloid malignancies. In this study, we focused on LEF1 isoforms in several hematological malignancies found tissue-specific differential full-length (FL)-LEF1 gene tumor suppressor (∆LEF1) variant. Material Method: Fifty-thre...
a 61-year-old female presented with complaints of fever, general weakness and hepatosplenomegaly. she had a history of nonfamilial peripheral neurofibromatosis diagnosed as von recklinghausen's disease since 30 years previous. physical examination was remarkable for skin colored cutaneous circumscribed nodules which appeared soft to the touch in both arms, the upper part of her abdomen, back, a...
Investigation of Leptin, Leukemia Inhibitory Factor (LIF), and IL-6 Serum Levels in Myeloid Leukemia
Background: Leptin has been implicated in the differentiation and proliferation of hematopoietic cells. Leukemia inhibitory factor (LIF) may play an important role, along with Interleukin-6 (IL-6) and granulocyte colony stimulating factor (G- CSF), in the regulation of early hematopoietic stem cells. The aim of the study was to evaluate serum level of leptin, LIF, and IL-6 in myeloid leukemia p...
Existing in vitro culture technology does not permit the routine propagation of most human myeloid leukemias. Previous work has shown the usefulness of mice with severe combined immunodeficiency (SCID) for the growth of human lymphoblastic leukemia. We show here that human myeloid cell lines and bone marrow samples from patients with acute myeloid leukemia (AML) and blast crisis of chronic myel...
Based on the privileged fragment-based drug design strategy, a series of imatinib analogues bearing moiety 3-(2-amino- 2-oxoacetyl)-1H-indole were designed and synthesized, in vitro antitumor activity these compounds was detected by MTT method using K562 (human myeloid leukemia) K562R (imatinib-resistant chronic cell lines. Molecular docking used to preliminarily explain possible binding modes....
Background and purpose: Chronic myeloid leukemia (CML) is the most widely recognized form of leukemia. Nowadays, trying to find new synthetic compounds is one of the basic strategies to find new drugs to treat CML. In present study the effects of some of Pyrimidone derivatives on proliferation, viability, and apoptosis of human leukemia K562 cell line as experimental model for CML have been inv...
Background: Leukemia is one of the major causes of mortality and disability and the seventh most prevalent cancer worldwide. It has various effects on different aspects of physical, psychological, reproductive, social, and economic performance of human life. This study compared the quality of life of patients with different types of leukemia hospitalized in Ayatollah Khansari Hospital in Arak- ...
investigation of leptin, leukemia inhibitory factor (lif), and il-6 serum levels in myeloid leukemia
background: leptin has been implicated in the differentiation and proliferation of hematopoietic cells. leukemia inhibitory factor (lif) may play an important role, along with interleukin-6 (il-6) and granulocyte colony stimulating factor (g- csf), in the regulation of early hematopoietic stem cells. the aim of the study was to evaluate serum level of leptin, lif, and il-6 in myeloid leukemia p...
Lectins (carbohydrate-binding proteins) are able to distinguish different patterns of glycosylation on cell surfaces. This study investigated the effects lectins from Alpinia purpurata inflorescence (ApuL) and Schinus terebinthifolia leaf (SteLL) viability human leukemia cells (K562, chronic myeloid leukemia; JURKAT, acute lymphoblastic leukemia) mesenchymal stem (MSCs) umbilical cords. In addi...
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