Recent studies indicate the importance of the ubiquitin ligase Siah2 in control of more aggressive prostate tumors – namely, neuroendocrine (NE) prostate tumors and prostate adenocarcinoma (PCa) harboring neuroendocrine lesions. Siah2-dependent expression and activity of HIF-1α regulate its availability to form a transcriptional complex with FoxA2, resulting in expression of specific target gen...

Angiogenesis, formation of new blood vessels, is essential for tumor progression, invasion, and metastasis. 1 Vascular endo-thelial growth factors (VEGFs) and their receptors (VEGFRs) are primary regulators of angiogenesis, coordinating with other angiogenic factors such as fibroblast growth factors (FGFs), hepatic growth factor (HGF), angiopoietins, and Notch-Dll4. Anti-VEGF antibodies (e.g., ...