The CXC chemokine ligand (CXCL12, or stromal cell-derived factor-1 as previously known) plays a critical role for homing and retention of chronic lymphocytic leukemia (CLL) cells in tissues such as the bone marrow (BM). In tissues, stromal cells constitutively secrete and present CXCL12 via cell-surface-bound glycosaminoglycans (GAGs), thereby attracting CLL cells and protecting them from cytot...

La problemática tratada en este artículo está relacionada con la valoración de los recursos (humanos, económicos, tecnológicos y metodológicos) dentro Universidad Michoacana San Nicolás Hidalgo (UMSNH), un sistema causas efectos del proceso enseñanza-aprendizaje educación superior. El objetivo es entender sinergias una universidad pública a través participación actores clave las funciones esta....

PURPOSE The insulin-like growth factor-I receptor (IGF-IR) and its ligands have been implicated in the pathogenesis and progression of various cancers, including those arising in the thyroid gland. We therefore evaluated whether the IGF-IR could serve as a potential target for therapy of anaplastic thyroid carcinoma (ATC). EXPERIMENTAL DESIGN The expression and activation of the IGF-IR and so...

The ORDO review group was an influential German-speaking liberal school made up of outstanding economists. One those leaders Wilhelm Röpke, who did a critical the political economy development during social policy period. Our aim is to show its advisability in order reconsider role state at «the post-welfarist age». Röpkean thought based on humanistic approach economy, from which he criticized ...

The present paper thoroughly explores second-best efficient allocations in an adverse selection insurance economy. We start from a natural extension of the classical model, assuming less than perfect risk perceptions. We propose first and second welfare theorems, by means of which we describe efficiencyenhancing policies. Notions of weak and strong adverse selection are promising for interpreti...

We determined virulence of seven Heterorhabditis bacteriophora strain GPS11 inbred lines possessing superior infective juvenile longevity, and heat and ultra violet radiation tolerance against white grubs Popillia japonica and Cyclocephala borealis. At 1 and 2 weeks after treatment, inbred line A2 was significantly more virulent towards P. japonica compared to the parent strain GPS11 and inbred...

in this paper we investigate the long memory of tehran securities price index and fit arfima model using 970 daily data since 1382/1/6 until 1386/4/17. furthermore, we compare the forecasting performance of arfima and arima models. the results show that the series is a long memory one and therefore it can become stationary by fractional differencing. we obtaine the fractional differencing param...