نتایج جستجو برای: janus kinase
تعداد نتایج: 230213 فیلتر نتایج به سال:
BACKGROUND Hypereosinophilic syndrome is a hematologic disorder in which the eosinophils proliferate. Oral Janus kinase inhibitors are known to be effective treating hypereosinophilic syndrome. Janus kinase inhibitors have also demonstrated efficacy in alopecia. Madarosis is a condition in which the eyelashes are missing or absent and can been seen in alopecia patients. CASE PRESENTATION We p...
Janus kinase (JAK) inhibitors are being developed for the treatment of rheumatoid arthritis, psoriasis, myeloproliferative neoplasms, and leukemias. Most of these drugs target the ATP-binding pocket and stabilize the active conformation of the JAK kinases. This type I binding mode can lead to an increase in JAK activation loop phosphorylation, despite blockade of kinase function. Here we report...
During Drosophila oogenesis the follicular epithelium becomes subdivided into distinct cell populations. New reports have established that the Janus kinase (JAK) signalling pathway plays an important role in this process.
Background: Chronic urticaria is a long-lasting condition, sometimes with serious comorbidities, severely affecting the quality of life, which makes patients seek efficient therapies to achieve sustained remissions. The complex nature greatly complicates patients’ responses appropriate treatments. Objectives: This review was conducted focus on Janus kinase (JAK) pathway, evaluate its role as ne...
Tofacitinib, ein Janus-Kinase (JAK)-Inhibitor, ist eine wichtige Therapieoption für RA-Patienten mit hoher Krankheitsaktivität. In den letzten Jahren es zu Sicherheitsbedenken im Zusammenhang dem Auftreten venöser Thromboembolien bei Behandlung JAK-Inhibitoren gekommen. Desai et al. kamen nun Erkenntnissen über das Risiko venöse Rahmen einer Tofacitinib-Behandlung RA-Patienten.
Janus kinase 2 (JAK2) is a protein tyrosine kinase that transduces cellular signals through the Janus kinase signal transducer and an activator of transcription pathways (JAK-STAT), which mediates cell growth, differentiation, apoptosis, transformation, and other fundamental cell functions, and is active in both normal hematopoiesis and hematological malignancies. Tyrosine kinase protein mutati...
Cellular responses to dozens of cytokines and growth factors are mediated by the evolutionarily conserved Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway (Fig. 1). These responses include proliferation, differentiation, migration, apoptosis, and cell survival, depending on the signal, tissue, and cellular context. JAK/STATsignaling is essential for n...
Various cytokines are involved in the regulation of the immune system and inflammation. Dysregulation of cytokine signaling can cause a variety of diseases, including allergy, autoimmune diseases, inflammation, and cancer. Most cytokines use the so-called janus kinase/signal transducer and activator of transcription pathway, and this pathway is negatively regulated by suppressors of cytokine si...
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