[Full Text] [Abstract] , January 1, 2004; 286 (1): E116-E122. Am J Physiol Endocrinol Metab A. R. Diani, G. Sawada, B. Wyse, F. T. Murray and M. Khan murine models of type 2 diabetes Pioglitazone preserves pancreatic islet structure and insulin secretory function in three [PDF] [Full Text] [Abstract] , March 1, 2005; 288 (3): E510-E518. Am J Physiol Endocrinol Metab F. Kawasaki, M. Matsuda, ...

The C57BLKS/J-Lepr(db) mouse has a point mutation in the leptin receptor gene and is one of the most useful animal model for non-insulin dependent diabetes mellitus in human. Since the homozygote of C57BLKS/J-Lepr(db) mouse is infertile, detection of point mutation in the leptin receptor gene is important for efficient maintaining strains as well as mass production of homozygotes. To develop a ...

introduction: burning mouth syndrome (bms) is defined as burning and pain in the oral mucosa usually without any clinical and laboratory findings. it has a negative effect on patients' quality of life and can be a significant health problem. the aim of this study was to identify major risk factors associated with bms in menopausal and non-menopausal women at dental clinics of gorgan, iran. meth...

PREPARATION FOR THE RETURN OF STARDUST G. A. Graham, A. L. Butterworth, M. J. Burchell, A. T. Kearsley, J. A. Creighton, J. Mann, P. A. Bland, G. Cressey, C. G. Jones , M. M. Grady and I. P. Wright, Planetary and Space Sciences Research Institute (PSSRI), The Open University, Milton Keynes MK7 6AA, U.K ([email protected]), School of Physical Sciences, University of Kent, Canterbury CT2 7NR,...

Analogues of BMS-284756, a novel des-F(6)-quinolone, were synthesized and evaluated in order to determine the effects of modification of substituents on in vitro target inhibition. BMS-340281 (stereoisomer of BMS-284756), BMS-340280 (C-6 fluorinated analogue of BMS-284756), BMS-340278 (C-8-H derivative), BMS-433366 (C-8 methoxy analogue) and fluoroquinolone comparators were evaluated for antiba...

BACKGROUND BMS-663068 is a prodrug of the small-molecule inhibitor BMS-626529, which inhibits human immunodeficiency virus type 1 (HIV-1) infection by binding to gp120 and interfering with the attachment of virus to CD4+ T-cells. METHODS Fifty HIV-1-infected subjects were randomized to 1 of 5 regimen groups (600 mg BMS-663068 plus 100 mg ritonavir every 12 hours [Q12H], 1200 mg BMS-663068 plu...

Stent thrombosis (ST) after percutaneous coronary intervention has been the focus of intense interest because of its attendant morbidity and mortality. There is controversy about several facets of the problem. These include the frequency of ST with drug-eluting stents (DES) versus bare-metal stents (BMS), the timing of the event, clinical consequences, risk factors, adjunctive therapy, and new ...

An acidic polysaccharide of Panax ginseng (APG), so called ginsan is known to have important immunomodulatory activities. It was recently reported that APG has radioprotective effects in mice but the detailed mechanism was not fully elucidated. This study examined the effects of APG on bone marrow cells (BMs). The phenotypical and functional changes in APG-treated BMs after gamma radiation were...