Trypanosome RNA editing is a unique U insertion and U deletion process that involves cycles of pre-mRNA cleavage, terminal U addition or U removal, and religation. This editing can occur at massive levels and is directed by base pairing of trans-acting guide RNAs. Both U insertion and U deletion cycles are catalyzed by a single protein complex that contains only seven major proteins, band I thr...

OBJECTIVE The purpose of this study was to identify the various patterns of insertion of the anterior horn of the medial meniscus in Ghanaian subjects. STUDY The study involved 35 cadaveric knees (26 males and 9 females). Berlet and Fowler classification was used to classify the insertion of the anterior horn of the medila meniscus. FINDINGS The distribution of the insertion pattern was as ...

Background and Significance: Many hospitalized patients require an intravenous (IV) catheter to maintain vascular access or for administration of fluids and medications. The best approach to attaining peripheral intravenous (PIV) access for long term therapy is unknown, particularly in patients with a history of difficult IV placement. Purpose: To measure clinical outcomes using a Modified Seld...

pain in icu patients should be managed effectively and safely. fentanyl and paracetamol are used frequently in icu. however experience using iv paracetamol in the setting of critically ill patients is limited. we evaluated the analgesic effect and adverse reactions of intravenous paracetamol compared to fentanyl in icu patients with mild to moderate pain. forty patients in a general icu were ra...

Peripheral intravenous (IV) catheters can break off while still in the patient, with possible detrimental effects such as upstream migration to the heart. These catheters have probably been damaged by the needle during a difficult insertion. A peripheral IV catheter was removed in a 90 year old patient and only half of the catheter was retrieved. By using ultrasound examination the remaining pa...

background carbapenemes are a good choice for treatment of infections caused by multidrug resistant pseudomonads aeruginosa. the emergence of carbapenem resistance has become a major problem in treatment of this organism especially among immunocompromised patients including burn patients. objectives the aim of this study was to investigate carbapenem-resistance mechanisms among burn patients in...

DNA adducts, which block replicative DNA polymerases (DNAPs), are often bypassed by lesion-bypass DNAPs, which are mostly in the Y-Family. Y-Family DNAPs can do non-mutagenic or mutagenic dNTP insertion, and understanding this difference is important, because mutations transform normal into tumorigenic cells. Y-Family DNAP architecture that dictates mechanism, as revealed in structural and mode...